关键信息
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基因名
USP46
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简介
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
- 应用
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别名
USP46; Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
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种属
Human
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表达系统
E. coli
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标签
N-6*His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P62068
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表达区间
M1-E366
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
USP46 (Ubiquitin Specific Peptidase 46) is a deubiquitinating enzyme that plays a crucial role in protein homeostasis and cellular signaling by removing ubiquitin moieties from target proteins, thus regulating their stability and function. Recent studies have highlighted its significance in various biological processes, including neurodevelopment, apoptosis, and immune response. Dysregulation of USP46 has been linked to several diseases, including neurodegenerative disorders and cancer. Given its importance, researchers have focused on understanding the structural and functional mechanisms of USP46, exploring its substrate specificity and interactions with other cellular components. Structural characterization of USP46 through techniques like X-ray crystallography and NMR has provided insights into its enzymatic activity and regulatory mechanisms, which could pave the way for the development of novel therapeutics targeting this enzyme. Furthermore, the potential of USP46 as a biomarker for certain diseases is being investigated, emphasizing its relevance in clinical research. As such, ongoing studies aim to elucidate the comprehensive role of USP46 in cellular biology, aiming to harness its therapeutic potential in combating diseases associated with aberrant ubiquitin signaling.
