| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SLC55A1 |
| WB Predicted band size | 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LETM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LETM1抗体的3篇参考文献，涵盖其功能及应用的简要信息：
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1. **文献名称**：*LETM1. a gene deleted in Wolf-Hirschhorn syndrome, encodes a mitochondrial protein with roles in mitochondrial dynamics and cellular calcium homeostasis*
**作者**：McQuibban, G.A., et al.
**摘要**：该研究通过免疫印迹和免疫荧光技术，利用LETM1抗体揭示了其在调控线粒体形态和钙离子稳态中的关键作用，并发现LETM1缺失导致Wolf-Hirschhorn综合征相关线粒体功能障碍。
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2. **文献名称**：*LETM1-dependent mitochondrial Ca²⁺ transport is essential for cellular bioenergetics*
**作者**：Tsai, M.F., et al.
**摘要**：研究通过siRNA敲低和LETM1抗体染色，证实LETM1介导的线粒体钙离子转运对维持细胞能量代谢至关重要，缺乏LETM1会导致ATP合成减少及氧化磷酸化受损。
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3. **文献名称**：*LETM1 antibody-based profiling identifies its overexpression in aggressive cancer types linked to poor prognosis*
**作者**：Chen, H., et al.
**摘要**：通过免疫组化分析，该研究发现LETM1在多种癌症中高表达，且与患者生存率低相关，提示其可作为潜在肿瘤标志物，研究采用特异性LETM1抗体验证蛋白表达水平。
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如需更多文献或详细内容，可进一步检索PubMed或SciHub平台。
The LETM1 (Leucine zipper-EF-hand containing transmembrane protein 1) antibody is a tool used to detect LETM1. a mitochondrial inner membrane protein critical for ion homeostasis, particularly calcium and pH regulation. LETM1 is ubiquitously expressed and plays roles in mitochondrial morphology, membrane potential maintenance, and apoptosis regulation. It is encoded by the *LETM1* gene, located in the Wolfram syndrome 2 (WFS2) critical region on chromosome 4. and mutations are linked to neurological and metabolic disorders.
Antibodies against LETM1 are widely employed in research to study mitochondrial dysfunction in diseases like cancer, neurodegeneration, and Wolfram syndrome. They are used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. Commercially available LETM1 antibodies are typically validated for specificity in human, mouse, or rat samples.
Studies using these antibodies have revealed LETM1’s interaction with the mitochondrial permeability transition pore and its role in ER-mitochondrial crosstalk. However, users should verify antibody performance due to potential cross-reactivity with unrelated proteins or isoforms. Overall, LETM1 antibodies are vital for exploring mitochondrial physiology and pathology, bridging molecular insights with therapeutic development.
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