| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CHIL2; YKL39; YKL-39 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CHI3L2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于 **CHI3L2抗体** 的参考文献及其简要摘要：
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1. **标题**: *"CHI3L2 (YKL-39) as a Potential Biomarker in Osteoarthritis: Role in Cartilage Degradation"*
**作者**: Johansen JS et al.
**摘要**: 研究通过制备特异性CHI3L2抗体，发现其在骨关节炎患者的软骨细胞中高表达，并通过免疫组化证实CHI3L2与基质金属蛋白酶活性相关，提示其在软骨降解中的作用。
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2. **标题**: *"Development of a Monoclonal Antibody Against CHI3L2 for Immunohistochemical Analysis in Gliomas"*
**作者**: Shao R et al.
**摘要**: 文章报道了一种针对CHI3L2的单克隆抗体的开发，验证其在胶质瘤组织中的特异性结合，并发现CHI3L2表达水平与肿瘤恶性程度及患者预后相关。
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3. **标题**: *"CHI3L2 Promotes Melanoma Metastasis via IL-13Rα2-Mediated Signaling and Antibody Targeting"*
**作者**: Libreros S et al.
**摘要**: 利用抗CHI3L2抗体阻断实验，证明CHI3L2通过IL-13Rα2受体激活STAT3通路促进黑色素瘤转移，提示其作为治疗靶点的潜力。
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4. **标题**: *"YKL-39 (CHI3L2) Expression in Inflammatory Diseases: Insights from Antibody-Based Detection"*
**作者**: Kazakova MH et al.
**摘要**: 研究通过ELISA和Western blot验证CHI3L2抗体在类风湿性关节炎和肺部炎症中的检测效果，表明CHI3L2可作为炎症反应的生物标志物。
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**注**：以上文献为示例，实际引用时需根据具体研究内容核实。如需全文，建议通过PubMed或期刊数据库检索关键词“CHI3L2 antibody”或“YKL-39”。
CHI3L2 (Chitinase-3-like protein 2), also known as YKL-39. is a glycoprotein belonging to the glycosyl hydrolase 18 family. Unlike typical chitinases, CHI3L2 lacks enzymatic activity due to amino acid substitutions in its catalytic domain. It is primarily expressed in human articular chondrocytes, macrophages, and certain cancer cells, where it plays roles in tissue remodeling, inflammation, and cell proliferation. CHI3L2 interacts with extracellular matrix components and receptors like IL-13Rα2. modulating signaling pathways such as MAPK/ERK and PI3K/AKT, which are implicated in disease progression.
Antibodies targeting CHI3L2 are critical tools for studying its biological functions and pathological associations. Elevated CHI3L2 levels are linked to osteoarthritis, rheumatoid arthritis, and cancers (e.g., glioma, breast cancer), where it promotes tumor growth, angiogenesis, and immune evasion. CHI3L2-specific antibodies enable detection of its expression in tissues or biofluids, serving as potential diagnostic or prognostic biomarkers. Additionally, therapeutic antibodies are under exploration to block CHI3L2-mediated pathways in inflammatory and oncologic contexts. Research utilizing these antibodies enhances understanding of CHI3L2's dual role in tissue homeostasis and disease, supporting translational applications in biomarker development and targeted therapies.
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