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Rabbit Polyclonal GM2A Antibody

  • 中文名: GM2A抗体
  • 别    名: SAP-3; GM2-AP
货号: IPDX09151
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesSAP-3; GM2-AP
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human GM2A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于GM2A抗体的参考文献摘要(注:文献为示例性内容,实际文献需通过学术数据库检索):

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1. **文献名称**: *"The role of GM2A in lysosomal lipid metabolism and Tay-Sachs disease"*

**作者**: Chen H. et al.

**摘要**: 本研究通过构建GM2A基因敲除小鼠模型,利用特异性GM2A抗体检测其蛋白表达缺失对溶酶体GM2神经节苷脂降解的影响,揭示了GM2A在脂质代谢中的关键作用,并探讨其与泰-萨克斯病发病机制的关联。

2. **文献名称**: *"Development of a monoclonal antibody targeting GM2 activator protein for diagnostic applications"*

**作者**: Smith J.R. & Patel K.

**摘要**: 报道了一种高特异性抗人GM2A单克隆抗体的开发,该抗体通过ELISA和免疫组化验证,可用于溶酶体贮积症患者血清中GM2A水平的定量检测及组织病理分析。

3. **文献名称**: *"Structural insights into GM2A-lipid interactions via antibody-based epitope mapping"*

**作者**: Yamamoto S. et al.

**摘要**: 利用抗GM2A抗体进行表位定位研究,结合X射线晶体学解析GM2A蛋白与脂质结合的结构域,阐明了其介导GM2神经节苷脂水解的分子机制。

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如需具体文献,建议在PubMed或Web of Science中检索关键词“GM2A antibody”或联系相关领域综述获取更详细引用。

背景信息

GM2A antibody targets the GM2 activator protein (GM2AP), a crucial cofactor in lysosomal lipid metabolism. GM2AP facilitates the hydrolysis of GM2 gangliosides by β-hexosaminidase A, enabling the breakdown of complex lipids into simpler components. Deficiencies in GM2AP cause AB-variant GM2 gangliosidosis, a rare lysosomal storage disorder characterized by progressive neurodegeneration due to GM2 accumulation in neuronal cells. The GM2A antibody is primarily used in research to study GM2AP expression, localization, and function, aiding in the diagnosis and mechanistic understanding of lysosomal disorders. It is also employed in immunoassays, Western blotting, and immunohistochemistry to assess protein levels in cellular or tissue samples. Studies utilizing this antibody contribute to exploring therapeutic strategies, such as enzyme replacement or substrate reduction therapy, for GM2-related diseases. Additionally, GM2A antibodies help investigate the protein’s role beyond lipid metabolism, including potential involvement in immune modulation and membrane repair processes. Their development and application underscore the intersection of biochemistry, neurology, and molecular medicine in addressing inherited metabolic diseases.

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