Rabbit Polyclonal NUDT12 Antibody

The NUDT12 antibody is a research tool designed to detect and study the NUDT12 protein, a member of the Nudix hydrolase family. NUDT12. also known as diadenosine tetraphosphate hydrolase, is an enzyme that hydrolyzes nucleotide derivatives, including diadenosine polyphosphates (e.g., Ap4A) and coenzyme A (CoA), playing a role in regulating cellular nucleotide pools and redox homeostasis. It is implicated in metabolic pathways, DNA repair, and stress responses. The gene encoding NUDT12 is conserved across eukaryotes, with studies suggesting its involvement in mitochondrial function and potential links to neurodegenerative diseases or cancer. Antibodies targeting NUDT12 are typically developed in immunized hosts (e.g., rabbits or mice) using peptide antigens or recombinant protein fragments. These antibodies enable applications such as Western blotting, immunofluorescence, and immunohistochemistry to analyze NUDT12 expression, localization, and interactions in cells or tissues. Commercial NUDT12 antibodies are often validated for specificity and sensitivity, though batch variability can occur. Research using NUDT12 antibodies has contributed to understanding its enzymatic activity, substrate preferences, and physiological roles, though its full biological significance remains under investigation. Such antibodies are critical for exploring NUDT12's potential as a biomarker or therapeutic target in metabolic disorders or oxidative stress-related pathologies.