关键信息
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基因名
GSTA1
- 应用
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别名
GSTA1; GST2; GSTA1-1; GTH1; GST class-alpha member 1; GST HA subunit 1; GST-epsilon; Glutathione S-transferase A1, N-terminally processed
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P08263
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表达区间
Ala2~Phe222
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GSTA1, or glutathione S-transferase A1, is an important enzyme belonging to the GST family that plays a crucial role in detoxifying harmful compounds by catalyzing the conjugation of glutathione to various electrophiles. It is implicated in the metabolism of xenobiotics, drug resistance, and oxidative stress responses. The study of GSTA1 has gained significance due to its involvement in various diseases, including cancer, where its overexpression may contribute to chemotherapy resistance. Additionally, its polymorphisms have been associated with differing susceptibility to toxins and drug efficacy among individuals. Research on recombinant GSTA1 proteins facilitates the understanding of its structure-function relationships, enzymatic mechanisms, and interactions with substrates. Furthermore, the production of functional recombinant GSTA1 protein allows scientists to explore innovative therapeutic strategies aimed at modulating GST activities in disease contexts. With advanced biotechnological methods, researchers seek to uncover the potential of GSTA1 as a biomarker for disease prognosis and as a target for novel drug designs, enhancing treatment outcomes by overcoming resistance mechanisms in patients. The comprehensive investigation of recombinant GSTA1 can contribute significantly to pharmacogenomics and personalized medicine, paving the way for tailored therapies based on individual metabolic profiles. This background underscores the relevance of GSTA1 research in both basic and applied biomedical sciences, highlighting its potential to improve therapeutic interventions and patient care.
