| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SMTCK |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CKMT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CKMT2抗体的参考文献示例(注：以下内容为示例性虚构，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *CKMT2 Expression in Colorectal Cancer: Prognostic Implications*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化分析CKMT2在结直肠癌组织中的表达，发现其高表达与患者不良预后显著相关，提示CKMT2可能作为潜在肿瘤标志物。
2. **文献名称**: *Mitochondrial Creatine Kinase CKMT2 Regulates Neuronal Energy Metabolism*
**作者**: Lee H, et al.
**摘要**: 利用CKMT2特异性抗体进行Western blot和免疫荧光实验，证实CKMT2缺失导致神经元线粒体ATP生成减少，影响突触功能，为神经退行性疾病机制提供新见解。
3. **文献名称**: *Development of a Monoclonal Antibody Targeting Human CKMT2 for Cardiac Studies*
**作者**: Garcia R, et al.
**摘要**: 报道一种高特异性抗CKMT2单克隆抗体的开发与验证，该抗体成功应用于心肌细胞模型，揭示CKMT2在心脏缺血再灌注损伤中的保护作用。
4. **文献名称**: *CKMT2 Antibody-Based Proteomic Analysis in Alzheimer's Disease*
**作者**: Chen L, et al.
**摘要**: 结合CKMT2抗体的蛋白质组学技术，发现阿尔茨海默病患者脑脊液中CKMT2水平异常，可能与线粒体功能障碍及认知衰退相关。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如“CKMT2 antibody”、“mitochondrial creatine kinase 2”)获取最新研究。
The CKMT2 antibody targets the creatine kinase mitochondrial 2 (CKMT2) protein, a key enzyme in cellular energy metabolism. CKMT2. also known as ubiquitous mitochondrial creatine kinase, is primarily located in the mitochondrial intermembrane space and plays a critical role in the phosphocreatine shuttle system. This system facilitates ATP regeneration by transferring high-energy phosphates from mitochondria to cytosolic sites, ensuring energy homeostasis in cells with high metabolic demands, such as cardiac and skeletal muscle, brain, and sperm cells. CKMT2 forms dimers or octamers, with its activity regulated by calcium, magnesium, and adenosine nucleotides.
Antibodies against CKMT2 are widely used in research to study mitochondrial function, energy metabolism disorders, and diseases linked to bioenergetic deficits, including neurodegenerative conditions, cardiomyopathies, and cancer. CKMT2 dysregulation has been implicated in tumor progression, as altered creatine kinase activity may promote cancer cell survival under hypoxic conditions. In immunostaining or Western blot applications, CKMT2 antibodies help assess protein expression levels, subcellular localization, and post-translational modifications. Specificity validation via knockout controls or siRNA knockdown is essential due to structural similarities with other creatine kinase isoforms. These tools advance understanding of CKMT2's role in health and disease, bridging metabolic pathways and cellular stress responses.
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