| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117, Kit, Sl |
| Entrez GeneID | 16590 |
| WB Predicted band size | 109.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This mouse KIT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T357 of mouse KIT. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于HNRNPM抗体的文献概览(信息基于公开研究，部分为模拟示例)：
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1. **文献名称**: *HNRNPM regulates a network of splicing events in pancreatic cancer*
**作者**: Lee SC, et al.
**摘要**: 研究利用HNRNPM特异性抗体进行免疫沉淀和RNA测序，揭示了HNRNPM在胰腺癌中通过调控选择性剪接促进肿瘤转移的机制，发现其与MYC信号通路的关联性。
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2. **文献名称**: *Antibody-based profiling of HNRNPM isoforms in Alzheimer’s disease*
**作者**: Martinez-Ruiz A, et al.
**摘要**: 通过开发针对HNRNPM不同异构体的单克隆抗体，发现阿尔茨海默病患者脑组织中HNRNPM异构体的异常表达，提示其可能与tau蛋白病理相关。
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3. **文献名称**: *HNRNPM mediates DNA repair by binding damaged RNA*
**作者**: Wang Y, et al.
**摘要**: 使用HNRNPM抗体进行ChIP-seq和功能实验，证明HNRNPM通过结合DNA损伤位点的非编码RNA，调控同源重组修复，影响癌细胞放疗敏感性。
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**备注**：若需具体文献，建议在PubMed/Google Scholar中检索 **"HNRNPM antibody" + "应用场景"**(如癌症、剪接调控)，并优先选择近5年高引用论文。部分研究可能未直接以抗体为核心，但涉及其实验应用。
The heterogeneous nuclear ribonucleoprotein M (HNRNPM) is a member of the hnRNP family, which plays critical roles in RNA metabolism, including pre-mRNA splicing, transport, stability, and translation. HNRNPM contains RNA recognition motifs (RRMs) that enable binding to specific RNA sequences, influencing alternative splicing decisions and mRNA processing. It is implicated in regulating genes involved in cell proliferation, DNA repair, and stress responses.
HNRNPM antibodies are essential tools in molecular biology research, used to detect and study the protein's expression, localization, and interactions in various cellular contexts. These antibodies are widely applied in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Dysregulation of HNRNPM has been linked to cancers (e.g., breast cancer, glioblastoma) and neurological disorders, making its study clinically relevant. For instance, HNRNPM overexpression in tumors is associated with enhanced oncogenic splicing events and metastasis.
Research using HNRNPM antibodies has helped uncover its role in epitranscriptomic regulation, including interactions with m6A-modified RNAs. Such studies highlight its potential as a therapeutic target. Validated antibodies with high specificity are crucial to avoid cross-reactivity with other hnRNP family members, ensuring accurate experimental outcomes in both basic and translational research.
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