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Rabbit Polyclonal DTX1 Antibody

  • 中文名： DTX1抗体
  • 别    名： hDx-1
货号: IPDX04823
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliaseshDx-1
WB Predicted band size67 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human DTX1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于DTX1抗体的3篇示例参考文献(注：部分内容可能为示例性概括，具体文献请通过学术数据库核实)：

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1. **文献名称**: *Deltex1 modulates protein kinase Cθ-mediated regulation of T cell activation*

**作者**: Smith A, et al.

**摘要**: 本研究探讨了DTX1在T细胞活化中的调控作用，通过抗DTX1抗体进行免疫沉淀和Western blot分析，发现DTX1与PKCθ相互作用并影响其信号通路，提示DTX1可能通过泛素化修饰调控T细胞免疫反应的强度。

2. **文献名称**: *DTX1-mediated ubiquitination regulates Notch signaling in B-cell malignancies*

**作者**: Chen L, et al.

**摘要**: 利用DTX1特异性抗体检测B细胞肿瘤样本中的蛋白表达，发现DTX1通过泛素化降解Notch通路抑制因子，促进淋巴瘤细胞增殖。研究为靶向DTX1-Notch轴的治疗策略提供了实验依据。

3. **文献名称**: *Antibody-based profiling of Deltex1 expression in triple-negative breast cancer*

**作者**: Wang Y, et al.

**摘要**: 通过免疫组化(IHC)和免疫荧光(IF)技术，使用商业化DTX1抗体分析三阴性乳腺癌组织。结果显示DTX1高表达与患者预后不良相关，提示其可能作为潜在生物标志物。

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**备注**：以上文献信息为示例性整理，实际研究中建议通过PubMed、Google Scholar等平台以“DTX1 antibody”、“Deltex1 function”等关键词检索最新文献，并注意选择抗体应用场景明确的论文(如验证抗体特异性、蛋白定位或功能研究)。

背景信息

The DTX1 antibody is a crucial tool in studying the Deltex1 (DTX1) protein, a member of the Deltex family of E3 ubiquitin ligases involved in the Notch signaling pathway. DTX1 plays a regulatory role in cellular processes such as differentiation, proliferation, and apoptosis by mediating protein ubiquitination and degradation. Initially identified as a Notch pathway modulator, DTX1 interacts with Notch receptors to influence downstream transcriptional activity, though its role can vary across cell types and contexts. Research has linked DTX1 to immune regulation, neurodevelopment, and cancer, where it may act as either an oncogene or tumor suppressor depending on the cellular environment. The DTX1 antibody enables detection and quantification of DTX1 expression in tissues or cell lines, aiding investigations into its functional mechanisms and disease associations. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies highlight DTX1's involvement in T-cell activation, B-cell malignancies, and drug resistance, underscoring its therapeutic and diagnostic potential. However, antibody specificity and validation remain critical considerations due to protein isoforms and cross-reactivity risks.

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