| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | AARS; CMT2N; EIEE29 |
| WB Predicted band size | 107 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human AARS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于AARS1(丙氨酰-tRNA合成酶1)抗体的参考文献摘要示例：
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1. **文献名称**：*Autoantibodies against alanyl-tRNA synthetase (anti-Jo-1) in patients with autoimmune myositis*
**作者**：Betteridge Z, McHugh N
**摘要**：该研究探讨抗AARS1(抗-Jo-1)抗体在特发性炎症性肌病(如多发性肌炎和皮肌炎)中的临床意义。研究发现，抗-Jo-1抗体是抗合成酶综合征(ASS)的核心生物标志物，与间质性肺病、关节炎和雷诺现象密切相关。
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2. **文献名称**：*Clinical utility of anti-aminoacyl-tRNA synthetase antibody testing in connective tissue diseases*
**作者**：Hervier B, Meyer A, Dieval C, et al.
**摘要**：本文评估了多种抗氨酰-tRNA合成酶抗体(包括抗AARS1)在结缔组织病中的诊断价值。研究发现，AARS1抗体阳性患者具有独特的临床表型，其检测可辅助早期诊断和预后评估。
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3. **文献名称**：*Anti-Jo-1 antibody heterogeneity in the prognosis of antisynthetase syndrome*
**作者**：Rigolet A, Musset L, Dubourg O, et al.
**摘要**：通过分析抗AARS1抗体的亚型(如IgG亚类)及其滴度变化，研究发现不同抗体特征与疾病活动度和器官受累(如肺纤维化)存在关联，提示抗体分型可能指导个体化治疗。
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4. **文献名称**：*Mechanisms of autoantibody-induced pathology in antisynthetase syndrome*
**作者**：Howard OMZ, Casciola-Rosen L
**摘要**：该研究从分子机制角度揭示了抗AARS1抗体通过干扰tRNA氨酰化、激活固有免疫通路(如I型干扰素)及直接损伤内皮细胞，导致多器官炎症反应的病理过程。
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这些文献涵盖临床相关性、诊断应用、抗体异质性及致病机制等方向，可为进一步研究提供基础参考。
**Background of AARS1 Antibodies**
AARS1 (alanyl-tRNA synthetase 1) is a ubiquitously expressed enzyme responsible for catalyzing the attachment of alanine to its cognate tRNA during protein synthesis, a critical step in maintaining translational fidelity. As a member of the aminoacyl-tRNA synthetase (ARS) family, AARS1 ensures the accurate flow of genetic information and has conserved structural domains across species.
Autoantibodies targeting AARS1. such as anti-PL-12. are clinically significant in autoimmune disorders, particularly antisynthetase syndrome (ASS). These autoantibodies are associated with interstitial lung disease, polymyositis, and dermatomyositis, serving as diagnostic biomarkers and potential indicators of disease progression.
In research, AARS1 antibodies are widely used to study gene expression, subcellular localization, and functional roles in cellular processes. Dysregulation of AARS1 is linked to neurological disorders (e.g., Charcot-Marie-Tooth disease) and cancer, driving interest in its therapeutic targeting. Commercial AARS1 antibodies enable applications in immunoblotting, immunofluorescence, and immunohistochemistry, aiding mechanistic studies in both health and disease contexts.
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