| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TIMP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TIMP4抗体的模拟参考文献示例(仅供参考，实际文献需通过学术数据库检索)：
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1. **文献名称**：*TIMP4 Expression in Colorectal Cancer: Prognostic Value and Antibody-Based Detection*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(使用特异性TIMP4单克隆抗体)分析了TIMP4在结直肠癌组织中的表达水平，发现其高表达与患者生存率负相关，提示TIMP4可能作为癌症预后的生物标志物。
2. **文献名称**：*Development of a Novel TIMP4-Specific Antibody for Cardiovascular Disease Research*
**作者**：Chen L, et al.
**摘要**：报道了一种新型TIMP4多克隆抗体的开发与验证，通过Western blot和免疫荧光证实其高特异性，并应用于动脉粥样硬化模型中TIMP4的蛋白定位及表达量分析。
3. **文献名称**：*TIMP4 Antibody Blockade Attenuates Myocardial Fibrosis in Hypertensive Rats*
**作者**：Wang Y, et al.
**摘要**：利用TIMP4中和抗体抑制其活性，发现可显著减少高血压大鼠模型的心肌纤维化，表明靶向TIMP4的抗体治疗在心血管疾病中的潜在应用。
4. **文献名称**：*Comparative Analysis of TIMP4 Antibody Performance in ELISA and Immunohistochemistry*
**作者**：Johnson R, et al.
**摘要**：系统比较了市售TIMP4抗体在ELISA定量与组织染色中的灵敏度和特异性，为不同实验场景下的抗体选择提供指导。
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**注**：以上为模拟文献，实际研究中建议通过PubMed、Web of Science等平台检索关键词(如“TIMP4 antibody”、“TIMP4 detection”)，并筛选涉及抗体开发、验证或应用的实证研究。
**Background of TIMP4 Antibody**
Tissue inhibitor of metalloproteinase 4 (TIMP4) is a member of the TIMP family, which regulates extracellular matrix (ECM) remodeling by inhibiting matrix metalloproteinases (MMPs). TIMP4 is expressed in various tissues, including the heart, brain, and reproductive organs, and plays dual roles in physiological processes (e.g., tissue repair) and pathological conditions (e.g., cancer, cardiovascular diseases, and fibrosis). Its dysregulation is linked to tumor progression, where it may either promote or suppress metastasis depending on context, and to cardiovascular pathologies like myocardial remodeling.
TIMP4 antibodies are essential tools for detecting and quantifying TIMP4 expression in research. They enable the study of TIMP4's role in ECM dynamics, cell signaling, and disease mechanisms through techniques like Western blotting, immunohistochemistry, and ELISA. These antibodies aid in exploring TIMP4 as a potential biomarker for disease diagnosis or therapeutic targeting. For instance, in cancer research, TIMP4 antibodies help assess its correlation with tumor stage and patient prognosis. Both polyclonal and monoclonal TIMP4 antibodies are available, with specificity validated for diverse experimental models. Ongoing research focuses on clarifying TIMP4's context-dependent functions and therapeutic applications.
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