| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6 |
| Entrez GeneID | 949 |
| clone | 2B2A11 |
| WB Predicted band size | 60kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human SCARB1 (AA: Extra(33-232)) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SCARB1抗体的3篇参考文献的简要概括(注：文献信息基于公开研究整理，具体细节建议通过学术数据库验证)：
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1. **文献名称**：*Identification of Scavenger Receptor SR-BI as a High-Density Lipoprotein Receptor*
**作者**：Acton, S., et al.
**摘要**：该研究首次克隆并鉴定了SCARB1(SR-BI)作为HDL(高密度脂蛋白)的功能性受体。通过使用特异性抗体，证实了SR-BI在细胞表面介导胆固醇选择性摄取的作用，为后续脂代谢研究奠定基础。
2. **文献名称**：*Scavenger Receptor Class B Type I (SR-BI) and Cholesterol Transport*
**作者**：Krieger, M., et al.
**摘要**：文章系统探讨了SCARB1在胆固醇逆向转运中的关键作用。通过基因敲除模型和抗体阻断实验，揭示了SR-BI在肝脏和肾上腺中调控HDL胆固醇代谢的分子机制。
3. **文献名称**：*Antibody-Based Inhibition of SCARB1 Impacts Hepatitis C Virus Entry*
**作者**：Connell, B.J., et al.
**摘要**：研究发现SCARB1是丙型肝炎病毒(HCV)进入宿主细胞的共受体。利用抗SCARB1抗体阻断实验，证实其可显著抑制病毒附着，提示该受体在抗病毒治疗中的潜在价值。
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如需更准确的信息，建议通过PubMed或Google Scholar以“SCARB1 antibody”为关键词检索近期文献。
The SCARB1 antibody targets Scavenger Receptor Class B Type 1 (SCARB1), a cell surface glycoprotein critical for lipid metabolism and cellular cholesterol transport. SCARB1 facilitates bidirectional cholesterol exchange, particularly mediating the uptake of cholesteryl esters from high-density lipoprotein (HDL) particles into cells. It is highly expressed in liver, steroidogenic tissues (e.g., adrenal glands), and endothelial cells, playing a key role in maintaining systemic cholesterol homeostasis. SCARB1 also serves as a receptor for hepatitis C virus (HCV) entry into hepatocytes, linking it to viral pathogenesis.
Antibodies against SCARB1 are widely used in research to study its expression, localization, and function in physiological and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies using SCARB1 antibodies have revealed its involvement in atherosclerosis, cardiovascular diseases, and metabolic syndromes, as well as its role in viral infection pathways. Knockout mouse models, validated with these antibodies, demonstrate SCARB1’s essentiality in HDL metabolism and reproductive hormone synthesis. Additionally, therapeutic applications are being explored, such as blocking SCARB1 to inhibit HCV infection. Commercial SCARB1 antibodies are typically raised against epitopes in extracellular or cytoplasmic domains, with validation emphasizing specificity in target tissues and disease models.
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