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Mouse Monoclonal CDX2 Antibody

  • 中文名： CDX2抗体
  • 别    名： CDX3; CDX-3; CDX2/AS
货号: IPD31978
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200-1/1000 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200-1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesCDX3; CDX-3; CDX2/AS
Entrez GeneID1045
clone5B4C1
WB Predicted band size33.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CDX2 (AA: 1-180) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CDX2抗体的3篇参考文献的简要信息：

1. **文献名称**：CDX2: A Highly Sensitive and Specific Marker of Colorectal Adenocarcinoma

**作者**：Werling RW, et al.

**摘要**：该研究验证了CDX2抗体在免疫组化中的应用，证明其在结直肠腺癌中具有高敏感性和特异性，可作为与其他胃肠道肿瘤鉴别诊断的重要标志物。

2. **文献名称**：CDX2 Expression in Gastric Intestinal Metaplasia and Gastric Cancer

**作者**：Mizoshita T, et al.

**摘要**：研究探讨了CDX2抗体在胃黏膜肠上皮化生和胃癌中的表达，发现CDX2在肠化生区域高表达，提示其在胃黏膜异常分化中的潜在作用。

3. **文献名称**：Utility of CDX2 Antibody in Distinguishing Primary Ovarian Carcinomas from Metastatic Gastrointestinal Carcinomas

**作者**：Vang R, et al.

**摘要**：该文献评估了CDX2抗体在鉴别卵巢原发癌与胃肠道转移癌中的价值，表明CDX2阴性有助于排除结直肠来源的转移性肿瘤。

背景信息

The CDX2 antibody is a valuable diagnostic tool in pathology, primarily used to identify the presence of the caudal-type homeobox transcription factor 2 (CDX2), a protein critical in intestinal development and differentiation. CDX2 is expressed in normal intestinal epithelial cells, where it regulates genes involved in cell polarity, proliferation, and apoptosis. Immunohistochemically, CDX2 antibodies (e.g., clone CDX2-88) are widely employed to confirm intestinal origin in tumors, particularly adenocarcinoma. Strong nuclear staining supports a diagnosis of colorectal carcinoma, aiding in distinguishing it from other adenocarcinomas (e.g., lung, ovarian). However, CDX2 expression is not entirely specific; it may be seen in gastric, pancreaticobiliary, or mucinous ovarian carcinomas. Loss of CDX2 expression in colorectal cancer has been associated with poor prognosis and microsatellite instability. In research, CDX2 antibodies help study gut development, Barrett’s esophagus, and intestinal metaplasia. Interpretation requires caution, as weak/patchy staining may occur in non-intestinal tissues. CDX2 is often used alongside other markers (CK20. SATB2) to enhance diagnostic accuracy. Its role extends to investigating tumor pathogenesis and therapeutic targets linked to intestinal differentiation pathways.

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