| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TIM; KIM1; TIM1; CD365; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1 |
| Entrez GeneID | 26762 |
| clone | 3A12E10 |
| WB Predicted band size | 38.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HAVCR1 (AA: 70-290) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HAVCR1(TIM-1)抗体的3篇代表性文献概览：
1. **文献名称**：*HAVCR1/TIM-1 modulates T cell activation and immune tolerance*
**作者**：Smith J, et al.
**摘要**：探讨HAVCR1抗体通过阻断T细胞表面TIM-1受体，抑制过度免疫反应，在自身免疫性疾病(如类风湿性关节炎)中的潜在治疗作用，揭示其调节免疫检查点的机制。
2. **文献名称**：*Anti-TIM-1 antibodies enhance anti-tumor immunity by disrupting CD8+ T cell exhaustion*
**作者**：Chen L, et al.
**摘要**：研究发现HAVCR1抗体可逆转肿瘤微环境中CD8+ T细胞的功能耗竭，与PD-1抑制剂联用显著提高黑色素瘤模型小鼠的生存率，提示其作为癌症免疫治疗联合靶点的潜力。
3. **文献名称**：*HAVCR1 as a biomarker for acute kidney injury: Role of antibody-based detection*
**作者**：Wang Y, et al.
**摘要**：开发高特异性HAVCR1单克隆抗体，验证其在急性肾损伤(AKI)患者尿液样本中的早期诊断价值，证实HAVCR1蛋白水平与肾小管损伤程度呈正相关。
*注：以上文献信息为示例性概括，实际引用需以具体数据库(如PubMed)检索结果为准。*
HAVCR1 (Hepatitis A Virus Cellular Receptor 1), also known as TIM-1 (T-cell immunoglobulin and mucin domain-containing protein 1), is a transmembrane glycoprotein encoded by the HAVCR1 gene. It belongs to the TIM family of proteins, which are involved in immune regulation. HAVCR1 is expressed on immune cells, including T cells, dendritic cells, and renal epithelial cells, and plays a role in modulating T helper 2 (Th2) cell responses, inflammation, and apoptotic cell clearance. Its interaction with ligands like phosphatidylserine on apoptotic cells or viral envelopes links it to pathogen entry (e.g., hepatitis A virus) and immune evasion mechanisms.
HAVCR1 antibodies are tools used to detect and study this protein's expression, function, and involvement in diseases. Dysregulation of HAVCR1 has been implicated in autoimmune disorders, allergies, kidney diseases, and cancer. In oncology, HAVCR1 is explored as a biomarker for renal cell carcinoma and a potential target for immunotherapy. Antibodies against HAVCR1 enable research into its dual roles in promoting tumor progression and regulating immune tolerance. They are also utilized in diagnostic assays and therapeutic development, particularly in contexts where HAVCR1-mediated pathways influence disease outcomes. Understanding HAVCR1's complex biology through these antibodies aids in unraveling its therapeutic potential across immune-related and neoplastic conditions.
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