| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MU; VH; AGM1 |
| Entrez GeneID | 3507 |
| clone | 9A8A4 |
| WB Predicted band size | 49.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是3条与IGHM抗体相关的假设参考文献示例(内容为虚构，仅作格式参考)：
---
1. **文献名称**: *Structural insights into the human IgM antibody by cryo-EM*
**作者**: Smith A, et al.
**摘要**: 通过冷冻电镜解析IGHM重链在IgM抗体中的三维结构，揭示了其与B细胞受体复合物的相互作用机制，为免疫应答研究提供新视角。
---
2. **文献名称**: *IGHM gene mutations cause early-onset agammaglobulinemia*
**作者**: Brown L, et al.
**摘要**: 研究发现IGHM基因缺陷导致B细胞发育停滞和低丙种球蛋白血症，揭示了IGHM在抗体多样性生成中的关键作用。
---
3. **文献名称**: *IGHM as a biomarker in chronic lymphocytic leukemia*
**作者**: Chen Z, et al.
**摘要**: 提出IGHM表达水平与慢性淋巴细胞白血病(CLL)患者预后相关，高IGHM可能提示更活跃的肿瘤B细胞克隆增殖。
---
注：实际文献需通过PubMed/Google Scholar检索，可使用关键词“IGHM antibody”“IgM heavy chain”或“IGHM gene”查找。
The immunoglobulin M (IgM) antibody, encoded by the IGHM gene, is a key component of the humoral immune response. As the first antibody produced during primary infection or vaccination, pentameric IgM plays a critical role in early pathogen neutralization and complement system activation. Its multivalent structure (five antibody units linked by a J-chain) enables high-avidity binding to antigens, compensating for lower individual binding affinity compared to IgG.
IgM exists in two forms: membrane-bound IgM serves as the B-cell receptor (BCR) on naive B cells, while secreted IgM circulates in blood and lymph. During B-cell development, productive rearrangement of the IGHM gene (chromosome 14) in pre-B cells is essential for progression to mature B lymphocytes. The variable region of the IgM heavy chain undergoes V(D)J recombination, generating antigen-binding diversity.
Defects in IgM production are linked to primary immunodeficiencies like agammaglobulinemia, while elevated IgM levels may indicate acute infection or certain autoimmune disorders. In clinical diagnostics, surface IgM serves as a marker for B-cell malignancies. Though short-lived in circulation (half-life ~5 days), IgM's rapid production and potent complement-activating capacity make it crucial for controlling pathogens before adaptive immunity fully develops. Recent research explores engineered IgM-based therapies leveraging its superior neutralization potential against multivalent antigens like viruses.
×
