Mouse Monoclonal ADRB2 Antibody

The β2-adrenergic receptor (ADRB2) is a G protein-coupled receptor (GPCR) widely expressed in smooth muscle, skeletal muscle, and other tissues, playing a critical role in regulating bronchodilation, vasodilation, and metabolic processes. ADRB2 antibodies are essential tools for detecting and quantifying this receptor in research and clinical contexts. These antibodies target specific epitopes on ADRB2. enabling its visualization in techniques like Western blotting, immunohistochemistry, and flow cytometry. ADRB2 dysfunction is linked to respiratory diseases (e.g., asthma, COPD), cardiovascular disorders, and metabolic syndromes. Genetic polymorphisms (e.g., Arg16Gly, Gln27Glu) in the ADRB2 gene (located on chromosome 5q31-q32) influence receptor activity and drug responses, such as β2-agonist efficacy in asthma. Researchers use ADRB2 antibodies to study receptor expression, localization, and signaling pathways (e.g., cAMP-mediated relaxation) in disease models or drug development. Specificity and validation (e.g., knockout controls) are critical, as cross-reactivity with other adrenergic receptors may occur. Understanding ADRB2's role through antibody-based assays aids in developing targeted therapies and personalized medicine approaches.