| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Tryptophan 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, TDO {ECO:0000255|HAMAP-Rule:MF_03020}, 1131111 {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptamin 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophan oxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, TO {ECO:0000255|HAMAP-Rule:MF_03020}, TRPO {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophan pyrrolase {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophanase {ECO:0000255|HAMAP-Rule:MF_03020}, TDO2 {ECO:0000255|HAMAP-Rule:MF_03020}, TDO |
| Entrez GeneID | 6999 |
| WB Predicted band size | 47.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TDO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TDO2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于VP2抗体的3篇参考文献示例(部分信息为模拟，供参考)：
1. **文献名称**：Production and characterization of monoclonal antibodies against VP2 protein of canine parvovirus
**作者**：Zhang Y, et al.
**摘要**：本研究制备了针对犬细小病毒VP2蛋白的单克隆抗体，验证了其特异性及在ELISA和免疫荧光检测中的应用，为病毒诊断提供了高效工具。
2. **文献名称**：Structural basis of VP2-mediated immune response in rotavirus vaccination
**作者**：Li H, et al.
**摘要**：通过冷冻电镜解析轮状病毒VP2蛋白与中和抗体的复合物结构，揭示了抗体结合表位及其中和机制，为疫苗优化提供理论依据。
3. **文献名称**：VP2-specific antibodies enhance protective immunity in mice against porcine parvovirus infection
**作者**：Wang J, et al.
**摘要**：评估了猪细小病毒VP2重组蛋白诱导的小鼠抗体反应，发现其能有效中和病毒并减少组织损伤，证明VP2作为疫苗抗原的潜力。
4. **文献名称**：Cross-species reactivity of VP2 antibodies in feline and mink parvoviruses
**作者**：Garcia-Diaz M, et al.
**摘要**：分析猫泛白细胞减少症病毒与水貂细小病毒VP2抗体的交叉反应性，发现保守表位抗体可提供跨物种部分保护，提示广谱疫苗研发可能性。
---
注：以上文献信息为示例性质，实际引用时需通过PubMed、Web of Science等平台检索真实文献。
**Background of VP2 Antibodies**
VP2 (Viral Protein 2) is a structural protein critical to the assembly and infectivity of several viruses, most notably in the *Parvoviridae* family (e.g., canine parvovirus, feline panleukopenia virus) and *Reoviridae* (e.g., rotavirus). In parvoviruses, VP2 forms the primary capsid, mediating host cell receptor binding, viral entry, and antigenic presentation. Antibodies targeting VP2 are central to immune responses, as they neutralize viral infectivity by blocking receptor interactions or destabilizing capsid integrity.
VP2 antibodies are widely used in diagnostics (e.g., ELISA, immunofluorescence) and research to detect viral infections or study capsid dynamics. In vaccine development, recombinant VP2 self-assembles into virus-like particles (VLPs), which elicit potent neutralizing antibodies without infectious material. For example, VP2-based vaccines are effective against canine parvovirus and poultry pathogens like infectious bursal disease virus (IBDV).
In rotaviruses, VP2 is an inner capsid protein involved in RNA replication and packaging. Antibodies against rotavirus VP2 are less common in diagnostics but aid in understanding replication mechanisms. Cross-reactivity studies of VP2 antibodies also shed light on evolutionary relationships among viral strains.
Overall, VP2 antibodies serve as vital tools for virology research, therapeutic development, and understanding host-pathogen interactions across diverse viral families.
×
