| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50 - 1/250 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | p72-Syk |
| Entrez GeneID | 6850 |
| clone | 2G11E6 |
| WB Predicted band size | 72kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SYK (AA: 217-356) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SYK抗体的3篇参考文献及其摘要信息：
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1. **文献名称**：*"Spleen tyrosine kinase (SYK) in chronic lymphocytic leukemia: Molecular signaling and therapeutic implications"*
**作者**：Gobessi, S. et al.
**摘要**：该研究探讨了SYK在慢性淋巴细胞白血病(CLL)中的异常激活及其对B细胞受体信号通路的调控作用，通过SYK抗体抑制实验证实其作为潜在治疗靶点的有效性，为临床开发SYK抑制剂提供了依据。
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2. **文献名称**：*"SYK signaling in dendritic cells orchestrates innate and adaptive immunity"*
**作者**：Mócsai, A. et al.
**摘要**：文章揭示了SYK激酶在树突状细胞中的关键作用，利用SYK特异性抗体阻断实验，证明其通过调控炎症因子分泌和T细胞活化，连接先天性与适应性免疫应答，为自身免疫疾病治疗提供新方向。
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3. **文献名称**：*"Targeting SYK with fostamatinib for rheumatoid arthritis: Clinical outcomes and biomarker analysis"*
**作者**：Weinblatt, M.E. et al.
**摘要**：该临床试验评估了SYK抑制剂Fostamatinib治疗类风湿关节炎的效果，研究中通过检测患者SYK抗体水平及磷酸化状态，发现其与药物响应率显著相关，提示SYK抗体可作为疗效预测标志物。
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以上文献涵盖了SYK抗体在疾病机制研究、免疫调控及临床应用中的关键作用，均为该领域的代表性研究。
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase critical for immune signaling, particularly in pathways activated by B-cell receptors (BCR) and certain Fc receptors. It plays a central role in regulating immune cell activation, proliferation, and survival. Structurally, SYK contains tandem SH2 domains that bind phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs), triggering downstream signaling cascades. Dysregulated SYK activity is implicated in autoimmune diseases (e.g., rheumatoid arthritis), hematologic malignancies (e.g., B-cell lymphomas), and inflammatory conditions, making it a therapeutic target.
SYK-specific antibodies are essential tools for studying its expression, phosphorylation status, and interactions in both physiological and pathological contexts. They enable detection of SYK in tissues/cells via techniques like Western blot, immunohistochemistry, and flow cytometry. Therapeutic anti-SYK antibodies are being explored to modulate immune responses or block oncogenic signaling. Small-molecule SYK inhibitors have shown clinical potential, but antibodies offer advantages in specificity for targeting extracellular epitopes or protein-protein interfaces. Research continues to clarify SYK's dual roles in immune regulation and disease pathogenesis, driving antibody-based diagnostic and therapeutic innovations.
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