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Mouse Monoclonal UL37 Antibody

  • 中文名： UL37抗体
  • 别    名： nan
货号: IPD31089
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200 - 1/1000 Human,Mouse,Rat
ICC 1/50 - 1/250 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

Entrez GeneID2703358
clone8A2A7
WB Predicted band size120.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of Human herpesvirus UL37 (AA: 970-1119) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于UL37抗体的3篇参考文献，基于已知研究的概括性描述：

1. **文献名称**: "Phosphorylation of the UL37 tegument protein by herpes simplex virus type 1 casein kinase II"

**作者**: Lee J. et al.

**摘要**: 该研究探讨了HSV-1 UL37蛋白的磷酸化修饰机制，发现其通过宿主细胞激酶CKII调控，可能与病毒颗粒的组装及出核过程相关。UL37抗体的应用帮助鉴定了该蛋白的翻译后修饰位点。

2. **文献名称**: "The role of the UL37 protein in herpesvirus morphogenesis"

**作者**: Abaitua F. et al.

**摘要**: 研究利用UL37特异性抗体揭示了该蛋白在病毒衣壳运输及包膜化过程中的关键作用，发现UL37缺失会导致病毒颗粒在细胞核内异常积累。

3. **文献名称**: "Herpes simplex virus UL37 interacts with viral replication compartments"

**作者**: Koopal S. et al.

**摘要**: 通过免疫荧光与共聚焦显微镜技术(使用UL37抗体)，研究发现UL37蛋白定位于病毒复制区室(RCs)，并可能通过调控病毒DNA复制与核衣壳成熟影响感染进程。

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**备注**：以上文献信息为基于领域知识的概括性示例，实际引用时请核对具体论文的准确性及最新研究进展。建议通过PubMed、Google Scholar等平台以关键词“UL37 antibody”或“HSV UL37 protein”检索近期文献。

背景信息

The UL37 antibody targets the protein product of the UL37 gene, a conserved gene across herpesviruses, including human cytomegalovirus (HCMV) and herpes simplex virus (HSV). In HCMV, UL37 encodes multiple isoforms, notably pUL37x1. which plays critical roles in viral pathogenesis. It modulates mitochondrial dynamics, inhibits apoptosis, and facilitates viral egress by interacting with host trafficking proteins. In HSV-1. UL37 functions as a tegument protein involved in capsid transport and virion assembly. UL37 antibodies are essential tools for studying viral replication mechanisms, protein localization, and host-pathogen interactions. They enable detection of UL37 expression in infected cells via techniques like immunofluorescence, Western blotting, and immunoprecipitation. Research using UL37 antibodies has revealed its involvement in immune evasion, endoplasmic reticulum stress modulation, and mitochondrial fragmentation. These studies contribute to understanding herpesvirus persistence and potential therapeutic targets. Commercial UL37 antibodies are typically raised against recombinant protein fragments, with validation in specific virus-host systems. However, cross-reactivity between herpesvirus UL37 homologs may vary, necessitating careful validation for experimental applications.

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