| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HOX2; HOX2F; HOX-2.6 |
| Entrez GeneID | 3214 |
| clone | 3A2F2 |
| WB Predicted band size | 27.6kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HOXB4 (AA: 16-251) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HOXB4抗体的3篇参考文献及其摘要概括(文献信息为虚构示例，仅供格式参考)：
1. **文献名称**：*HOXB4 Expression in Hematopoietic Stem Cells: A Role in Self-Renewal*
**作者**：Smith A et al.
**摘要**：研究通过Western blot和免疫荧光技术，使用HOXB4抗体验证其在造血干细胞中的高表达，发现HOXB4蛋白过表达可促进干细胞自我更新，抑制分化。
2. **文献名称**：*HOXB4 Antibody-Based Detection in Leukemia Progression*
**作者**：Chen L et al.
**摘要**：利用HOXB4单克隆抗体对白血病细胞系进行免疫组化分析，揭示HOXB4异常表达与白血病细胞增殖和耐药性相关，为靶向治疗提供依据。
3. **文献名称**：*Developmental Regulation of HOXB4 in Embryonic Tissues*
**作者**：Garcia R et al.
**摘要**：通过免疫组织化学结合HOXB4多克隆抗体，探究胚胎发育中HOXB4的时空表达模式，发现其在神经嵴和造血前体细胞中具有关键调控作用。
(注：以上文献为示例，实际文献需通过PubMed/Google Scholar等平台检索关键词“HOXB4 antibody”获取。)
HOXB4 antibodies are immunological tools used to detect and study the HOXB4 protein, a member of the homeobox (Hox) gene family. Hox genes encode transcription factors critical in embryonic development, particularly in establishing body patterning and cellular differentiation. HOXB4. located on chromosome 17. plays a key role in hematopoietic stem cell (HSC) self-renewal and differentiation, making it a focus in stem cell biology and regenerative medicine research. Studies show that HOXB4 overexpression enhances HSC expansion while maintaining pluripotency, suggesting therapeutic potential for bone marrow transplantation and blood disorder treatments.
HOXB4 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate its expression patterns in normal and malignant tissues. In cancer research, HOXB4 is implicated in both oncogenic and tumor-suppressive roles depending on context, with dysregulation observed in leukemia and solid tumors. Commercial HOXB4 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in various species and sample types. Researchers utilize these antibodies to explore HOXB4's interaction with signaling pathways (e.g., Wnt/β-catenin) and its role in maintaining stem cell niches. Proper antibody validation remains crucial due to potential cross-reactivity with other Hox family members.
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