Recombinant Human UL130 protein

中文名： 巨细胞病毒未鉴定蛋白UL130(UL130)重组蛋白
别名： UL130；VEGF165R2；Neuropilin-2

货号: PA2000-2533

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>90%SDS-PAGE.
种属	Human
靶点	UL130
Uniprot No	P16772
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	26-214aa
氨基酸序列	SPWSTLTANQNPSPPWSKLTYSKPHDAATFYCPFLYPSPPRSPLQFSGFQQVSTGPECRNETLYLLYNREGQTLVERSSTWVKKVIWYLSGRNQTILQRMPQTASKPSDGNVQISVEDAKIFGAHMVPKQTKLLRFVVNDGTRYQMCVMKLESWAHVFRDYSVSFQVRLTFTEANNQTYTFCTHPNLIV
预测分子量	37.7 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于UL130重组蛋白的假设性参考文献示例(请注意，这些文献为虚构，仅用于演示格式)：

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1. **文献名称**：*Structural and Functional Characterization of the Human Cytomegalovirus UL130 Recombinant Protein*

**作者**：Smith A, et al.

**摘要**：本研究通过重组表达HCMV UL130蛋白，解析其晶体结构，并验证其与UL128/UL131A形成的复合体在介导病毒上皮细胞感染中的关键作用，为靶向该复合体的抗病毒药物设计提供依据。

2. **文献名称**：*Immunogenicity of UL130 Recombinant Protein as a Component of a Novel CMV Vaccine*

**作者**：Zhang L, et al.

**摘要**：评估重组UL130蛋白联合其他糖蛋白(如gH/gL)在小鼠模型中的免疫原性，结果显示其可诱导中和抗体，显著抑制病毒对内皮细胞的感染，支持其作为候选疫苗的潜力。

3. **文献名称**：*Role of UL130 in HCMV Virion Assembly: Insights from Recombinant Mutagenesis*

**作者**：Johnson R, et al.

**摘要**：通过构建UL130重组突变体，发现其C端结构域对病毒粒子在成纤维细胞中的组装至关重要，突变后病毒滴度显著下降，揭示了UL130在病毒形态发生中的新功能。

4. **文献名称**：*Development of a UL130-Based Serodiagnostic Assay for CMV Infection*

**作者**：Wang Y, et al.

**摘要**：利用重组UL130蛋白建立ELISA检测方法，验证其在区分急性和潜伏性CMV感染中的高特异性与敏感性，为临床诊断提供新工具。

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**注意**：以上文献及作者为虚构，实际研究中请通过PubMed、Web of Science等平台检索真实文献。建议使用关键词“HCMV UL130 recombinant”或“CMV pentamer complex”查找相关研究。

背景信息

UL130 recombinant protein is a key component derived from human cytomegalovirus (HCMV), a herpesvirus that establishes lifelong latency and poses significant risks to immunocompromised individuals and neonates. UL130 is part of the HCMV envelope glycoprotein complex, specifically forming the pentameric gH/gL/UL128-131A complex, which is critical for viral entry into epithelial, endothelial, and myeloid cells. Unlike laboratory-adapted HCMV strains, which lose tropism for these cells due to mutations in UL130 or related genes, wild-type HCMV relies on this pentameric complex to mediate broad cellular tropism and efficient cell-to-cell spread.

Recombinant UL130 is typically produced using expression systems (e.g., mammalian or insect cells) to ensure proper post-translational modifications and structural integrity. It serves as a vital tool for studying HCMV entry mechanisms, neutralizing antibody responses, and vaccine development. Research has shown that antibodies targeting UL130 can potently neutralize HCMV infection, making it a focus for subunit vaccine design. Additionally, UL130's role in viral tropism underscores its importance in understanding HCMV pathogenesis and tissue-specific dissemination.

Efforts to develop HCMV vaccines, such as those targeting the pentameric complex, highlight UL130's clinical relevance. Its recombinant form enables scalable production for immunological studies and therapeutic candidate screening. Challenges remain in stabilizing the pentameric complex and eliciting durable immune responses, but UL130 remains a promising target for interrupting HCMV transmission and mitigating severe outcomes in high-risk populations.