| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | VIP36-like protein, Lectin mannose-binding 2-like, LMAN2-like protein, LMAN2L, VIPL |
| Entrez GeneID | 81562 |
| WB Predicted band size | 39.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LMAN2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-348 amino acids from the C-terminal region of human LMAN2L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LMAN2L抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *LMAN2L (ERGIC-3) is a potential regulator of protein secretion in the early secretory pathway*
**作者**: Zhang B, et al.
**摘要**: 该研究通过LMAN2L抗体验证了其在内质网-高尔基体中间区室(ERGIC)中的定位，发现LMAN2L可能通过调控特定糖蛋白的分泌参与早期分泌通路，并影响细胞分泌功能的稳定性。
2. **文献名称**: *LMAN2L modulates cell proliferation and migration in hepatocellular carcinoma*
**作者**: Liu Y, et al.
**摘要**: 利用LMAN2L抗体进行免疫组化分析，发现LMAN2L在肝癌组织中表达下调，可能通过调控ERK信号通路抑制肿瘤细胞的增殖和迁移，提示其作为肝癌潜在治疗靶点的可能性。
3. **文献名称**: *Characterization of LMAN2L as a novel trafficking adaptor in lysosomal enzyme transport*
**作者**: Schmidt K, et al.
**摘要**: 通过免疫沉淀和Western blot(使用LMAN2L抗体)发现，LMAN2L与溶酶体酶运输相关蛋白相互作用，可能作为转运适配分子参与溶酶体酶的成熟过程，影响细胞代谢稳态。
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注：以上文献为示例，实际文献需通过PubMed或学术数据库检索确认。LMAN2L抗体相关研究相对较少，建议结合其功能(如ERGIC复合物、分泌通路调控)扩展检索范围。
The LMAN2L (Lectin, Mannose Binding 2 Like) antibody is a tool used to detect and study the LMAN2L protein, a member of the vertebrate lectin family. LMAN2L shares homology with LMAN1 (ERGIC-53), a cargo receptor involved in glycoprotein transport between the endoplasmic reticulum (ER) and Golgi apparatus. Unlike LMAN1. which cycles between the ER and ER-Golgi intermediate compartment (ERGIC), LMAN2L is primarily localized to endosomal/lysosomal compartments, suggesting a distinct role in intracellular trafficking or protein sorting. The protein contains a carbohydrate-recognition domain (CRD), implying potential interactions with glycoproteins or glycolipids.
LMAN2L antibodies are commonly used in research to investigate the protein's expression, localization, and function. Studies suggest LMAN2L may participate in lysosomal enzyme trafficking, autophagy, or cellular stress responses, though its precise biological mechanisms remain unclear. Dysregulation of LMAN2L has been tentatively linked to lysosomal storage disorders and certain cancers, making it a subject of interest in disease pathology.
These antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunoprecipitation. Researchers rely on them to explore LMAN2L's interaction partners and regulatory pathways, contributing to broader understanding of intracellular transport networks and disease-associated molecular pathways.
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