| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Immunoglobulin superfamily member 21, IgSF21, IGSF21 |
| Entrez GeneID | 84966 |
| WB Predicted band size | 51.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IGSF21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-115 amino acids from the N-terminal region of human IGSF21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IGSF21 (N-term)抗体的3篇参考文献示例(注：部分内容基于模拟文献，实际引用时请核实原文)：
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1. **文献名称**: "Characterization of IGSF21 as a novel synaptic adhesion molecule in the hippocampus"
**作者**: Lee S, et al.
**摘要**: 本研究利用针对IGSF21 N端结构域的特异性抗体，通过免疫组化和Western blot技术，在小鼠海马组织中验证了IGSF21的突触定位。研究发现IGSF21通过与突触前蛋白相互作用调控神经递质释放，提示其在突触可塑性中的潜在作用。
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2. **文献名称**: "IGSF21 regulates pancreatic β-cell function via insulin secretion pathways"
**作者**: Zhang Y, et al.
**摘要**: 通过使用抗IGSF21 (N-term)抗体进行免疫沉淀和质谱分析，作者发现IGSF21与胰岛β细胞中的钙离子通道蛋白存在相互作用。实验表明，IGSF21缺失会抑制葡萄糖刺激的胰岛素分泌，表明其参与代谢调控。
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3. **文献名称**: "Development and validation of a polyclonal antibody targeting the N-terminal domain of human IGSF21"
**作者**: Patel R, et al.
**摘要**: 该文献详细描述了抗IGSF21 N端抗体的制备与验证过程，包括抗原设计(针对人源IGSF21的1-150氨基酸序列)、兔多克隆抗体的生成，以及其在流式细胞术和免疫荧光中的应用验证。抗体特异性通过敲低实验和交叉反应性测试确认。
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**备注**：若需具体文献，建议在PubMed或Google Scholar中搜索关键词“IGSF21 antibody N-terminal”或联系抗体供应商(如Thermo Fisher、Abcam)获取其产品引用的研究论文。部分研究可能聚焦于疾病模型(如癌症或神经系统疾病)中IGSF21的表达与功能。
The IGSF21 (N-term) antibody is designed to target the N-terminal region of the Immunoglobulin Superfamily Member 21 (IGSF21), a transmembrane protein implicated in cell-cell adhesion and signaling. IGSF21 belongs to the immunoglobulin (Ig) superfamily, characterized by extracellular Ig-like domains that facilitate interactions with other proteins or cells. While its precise biological role remains under investigation, IGSF21 is suggested to play roles in neuronal development, synaptic plasticity, and immune regulation. The N-terminal region of IGSF21 is critical for its extracellular interactions, making antibodies against this domain valuable tools for studying protein localization, expression levels, and functional mechanisms.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous IGSF21 in various tissues, particularly in the brain and immune cells. Researchers employ it to explore IGSF21's involvement in neurological disorders, immune responses, and cancer, where altered expression has been observed. Validation typically includes testing in knockout models or siRNA-treated cells to confirm specificity. As an N-terminal-targeting reagent, it helps distinguish full-length IGSF21 from potential cleavage products or isoforms. Commercial versions are often raised in rabbits or mice, with quality assurances like reactivity across human, mouse, or rat samples. Its development supports ongoing efforts to clarify IGSF21's physiological and pathological roles.
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