Rabbit Polyclonal GMCL1L Antibody

The GMCL1L (Germ Cell-less 1 Like Protein) antibody is a tool used to study the GMCL1L protein, a less-characterized member of the germ cell-less (GCL) protein family. GMCL1L shares homology with GCL proteins, which are implicated in germ cell development and transcriptional regulation. Structurally, it contains a BTB/POZ domain, suggesting roles in protein-protein interactions and chromatin remodeling. While its exact function remains unclear, GMCL1L is hypothesized to influence cell differentiation, apoptosis, or proliferation, potentially through interactions with proteins like DAZAP1. It has been detected in tissues such as testis, brain, and certain cancer cells. Research using GMCL1L antibodies focuses on elucidating its expression patterns, subcellular localization (e.g., nuclear vs. cytoplasmic), and involvement in diseases like cancer or infertility. The antibody is commonly applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies suggest GMCL1L may act as a tumor suppressor or oncogene depending on context, highlighting its dual potential in cancer biology. However, further validation is needed to clarify its mechanisms and therapeutic relevance. Commercial GMCL1L antibodies are typically raised against specific epitopes, often validated for reactivity in human or mouse models.