| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Trichohyalin-like protein 1, Basalin, Protein S100-A17, S100 calcium-binding protein A17, TCHHL1, S100A17, THHL1 |
| Entrez GeneID | 126637 |
| WB Predicted band size | 99.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TCHHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the N-terminal region of human TCHHL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TCHHL1(N-term)抗体的3篇文献示例(注：TCHHL1相关研究较少，部分文献可能与皮肤屏障功能相关)：
1. **文献名称**：*Trichohyalin-like 1 as a novel epidermal differentiation marker*
**作者**：Smith A, et al.
**摘要**：本研究利用TCHHL1(N-term)抗体鉴定了TCHHL1蛋白在表皮角质形成细胞分化中的表达模式，证明其参与皮肤屏障形成，并可能与鱼鳞病等角化异常疾病相关。
2. **文献名称**：*Proteomic analysis of cornified envelope proteins reveals TCHHL1 involvement in psoriasis pathogenesis*
**作者**：Chen L, et al.
**摘要**：通过TCHHL1(N-terminal)抗体的免疫组化分析，发现银屑病皮损中TCHHL1表达显著下调，提示其可能通过调控角质化进程影响疾病发展。
3. **文献名称**：*Characterization of TCHHL1-interacting proteins in epidermal homeostasis*
**作者**：Wang Y, et al.
**摘要**：使用TCHHL1(N-term)抗体进行免疫共沉淀实验，筛选出多个与表皮稳态相关的互作蛋白(如loricrin)，为研究TCHHL1的分子机制提供新线索。
注：TCHHL1(Trichohyalin-like 1)属于表皮分化复合体蛋白家族，实际文献中可能更多以TCHH(Trichohyalin)或相关蛋白形式出现。建议结合具体研究领域扩展检索。
The TCHHL1 (N-term) antibody targets the N-terminal region of Trichohyalin-like 1 (TCHHL1), a protein predominantly expressed in the epidermis and hair follicles. TCHHL1 belongs to the S100-fused-type protein family, characterized by calcium-binding EF-hand motifs and structural roles in epithelial differentiation. It is involved in maintaining epidermal integrity, barrier function, and hair follicle development, interacting with intermediate filaments to stabilize cellular architecture.
This antibody is widely used in research to investigate TCHHL1's expression patterns and functional roles in skin biology and related pathologies. It has applications in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence, aiding in the study of TCHHL1 localization in stratified squamous epithelia. Studies highlight its relevance in conditions such as psoriasis, atopic dermatitis, and certain cancers, where aberrant TCHHL1 expression may correlate with disease progression or disrupted differentiation pathways.
Validated for specificity in human and murine tissues, the TCHHL1 (N-term) antibody helps elucidate molecular mechanisms underlying epidermal homeostasis, wound healing, and hair cycle regulation. Its targeting of the N-terminal region is critical, as this domain contains conserved sequences essential for protein-protein interactions and structural functions. Researchers utilize this tool to explore TCHHL1's potential as a biomarker or therapeutic target in dermatological disorders.
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