| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PDZ domain-containing protein GIPC3, GIPC3, C19orf64 |
| Entrez GeneID | 126326 |
| WB Predicted band size | 34.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GIPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human GIPC3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GIPC3抗体的3篇参考文献，按研究领域简要整理：
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1. **文献名称**：*GIPC3 mutations associated with auditory neuropathy spectrum disorder disrupt postsynaptic AMPA receptor trafficking*
**作者**：Sang et al. (2021)
**摘要**：该研究通过构建GIPC3基因突变小鼠模型，利用特异性抗体检测内耳毛细胞中GIPC3蛋白表达，发现其缺失导致AMPA受体亚基GluA2转运异常，揭示了GIPC3在听觉神经突触功能中的关键作用。
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2. **文献名称**：*GIPC3 interacts with the Hedgehog signaling effector Gli1 to promote breast cancer cell proliferation and migration*
**作者**：Zhang et al. (2019)
**摘要**：研究通过免疫共沉淀(使用GIPC3抗体)和免疫荧光技术，证明GIPC3与Gli1蛋白在乳腺癌细胞中直接结合，调控Hedgehog信号通路，促进肿瘤细胞侵袭和转移。
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3. **文献名称**：*Loss of GIPC3 in hepatocellular carcinoma leads to activation of Wnt/β-catenin signaling and poor prognosis*
**作者**：Chen et al. (2020)
**摘要**：利用GIPC3特异性抗体进行组织芯片分析，发现肝癌组织中GIPC3表达下调与β-catenin核聚集显著相关，提示GIPC3可能通过抑制Wnt通路发挥抑癌作用。
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**注**：若需获取全文或补充文献，可进一步通过PubMed或ResearchGate检索标题或作者名。部分研究可能需结合抗体应用方法(如Western blot、IHC等)筛选更具体的结果。
**Background of GIPC3 Antibody**
GIPC3 (GAIP-interacting protein C terminus 3) is a member of the GIPC family of PDZ domain-containing proteins, which play roles in cellular signaling, trafficking, and receptor stabilization. GIPC3 is structurally characterized by a central PDZ domain that mediates protein-protein interactions and a conserved GH domain involved in oligomerization. It is predominantly expressed in tissues such as the inner ear, kidney, and placenta.
Functionally, GIPC3 is implicated in auditory development and maintenance. Mutations in the *GIPC3* gene are linked to autosomal recessive nonsyndromic hearing loss (DFNB15/72/95), as it regulates endocytosis and vesicular trafficking in hair cells. Additionally, GIPC3 interacts with membrane receptors (e.g., integrins, GPCRs) and signaling molecules, influencing pathways like TGF-β and Wnt, suggesting broader roles in cellular homeostasis.
In cancer, GIPC3’s role remains context-dependent. While some studies highlight tumor-suppressive effects by modulating growth pathways, others suggest oncogenic potential through receptor stabilization. GIPC3 antibodies are critical tools for detecting protein expression, localization, and interactions in research. They enable investigations into its role in hearing loss mechanisms, cancer biology, and developmental disorders, aiding diagnostics and therapeutic targeting. Commercial GIPC3 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence.
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