Rabbit Polyclonal MouseSmarcd1(Center) Antibody

中文名： Mouse Smarcd1(Center)抗体
别名： SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, 60 kDa BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, BAF60A, Protein D15KZ1, SWI/SNF complex 60 kDa subunit, Smarcd1, Baf60a, D15Kz1

货号: IPDX32261

Price： ￥1180

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	1/1000	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, 60 kDa BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, BAF60A, Protein D15KZ1, SWI/SNF complex 60 kDa subunit, Smarcd1, Baf60a, D15Kz1
Entrez GeneID	83797
WB Predicted band size	58.2kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Mouse
Immunogen	This Mouse Smarcd1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-335 amino acids from the Central region of mouse Smarcd1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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Mouse Smarcd1 Antibody (Center) (Cat. #P32261) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Mouse Smarcd1 antibody detected the Mouse Smarcd1 protein (arrow).

参考文献

以下是关于小鼠Smarcd1(Center)抗体的3篇参考文献示例(注：文献为虚构示例，实际引用需核实)：

1. **文献名称**: *"Smarcd1 regulates chromatin accessibility in murine embryonic stem cells"*

**作者**: Li et al. (2020)

**摘要**: 本研究利用Smarcd1(Center)特异性抗体，通过ChIP-seq和Western blot分析，揭示了Smarcd1在小鼠胚胎干细胞中维持染色质开放状态的关键作用，并证明其缺失导致多能性基因表达异常。

2. **文献名称**: *"Essential role of Smarcd1 in T-cell development revealed by conditional knockout models"*

**作者**: Martinez-Sanchez et al. (2018)

**摘要**: 通过免疫组化(使用Center抗体)和流式细胞术，作者发现Smarcd1在小鼠胸腺T细胞分化中调控关键转录因子，其缺失导致T细胞发育阻滞。

3. **文献名称**: *"Smarcd1 interacts with Brg1 to modulate hepatic lipid metabolism in mice"*

**作者**: Wang et al. (2021)

**摘要**: 研究使用Smarcd1抗体进行免疫共沉淀(Co-IP)实验，证实Smarcd1与Brg1在小鼠肝脏中协同调控脂质代谢相关基因，为代谢综合征机制提供了新见解。

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**注意**：以上文献为示例，实际引用需根据具体研究检索PubMed、Google Scholar等数据库，结合关键词“Smarcd1 antibody mouse”或“Smarcd1 chromatin remodeling”查找。建议通过抗体供应商(如CST、Abcam)官网获取其引用文献列表。

背景信息

**Background of Mouse SMARCD1 (Center) Antibody**

SMARCD1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1) is a core component of the SWI/SNF chromatin remodeling complex, which regulates transcriptional activation by modulating chromatin structure. This evolutionarily conserved complex utilizes ATP hydrolysis to reposition nucleosomes, thereby controlling access to DNA for transcription factors and other regulatory proteins. SMARCD1. specifically, plays a role in cellular differentiation, embryonic development, and tissue-specific gene expression. Dysregulation of SMARCD1 has been implicated in cancers and developmental disorders, highlighting its functional significance.

The Mouse SMARCD1 (Center) antibody is designed to detect endogenous SMARCD1 protein in mouse samples. It typically targets a central region of the protein, avoiding conserved domains shared with other SWI/SNF subunits (e.g., SMARCB1 or BRG1), ensuring specificity. This antibody is widely used in applications like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to study SMARCD1 expression, localization, and interactions in cellular models or tissues. Validation often includes testing in SMARCD1 knockout cells to confirm absence of signal, ensuring reliability.

As a research tool, this antibody aids in exploring SMARCD1's role in chromatin remodeling, its partnership with other SWI/SNF subunits, and its impact on gene regulatory networks in health and disease. Host species (e.g., rabbit or mouse) and clonality (monoclonal/polyclonal) vary by product, with optimization recommended for specific experimental conditions.