Recombinant Human CORO6 protein

中文名： 冠状蛋白E(CORO6)重组蛋白
别名： CORO6；Coronin-6

货号: PA1000-4283

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>85%SDS-PAGE.
种属	Human
靶点	CORO6
Uniprot No	Q6QEF8
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	1-472aa
氨基酸序列	MSRRVVRQSK FRHVFGQAAK ADQAYEDIRV SKVTWDSSFC AVNPKFLAII VEAGGGGAFI VLPLAKTGRV DKNYPLVTGH TAPVLDIDWC PHNDNVIASA SDDTTIMVWQ IPDYTPMRNI TEPIITLEGH SKRVGILSWH PTARNVLLSA GGDNVIIIWN VGTGEVLLSL DDMHPDVIHS VCWNSNGSLL ATTCKDKTLR IIDPRKGQVV AEQARPHEGA RPLRAVFTAD GKLLSTGFSR MSERQLALWD PNNFEEPVAL QEMDTSNGVL LPFYDPDSSI VYLCGKGDSS IRYFEITDEP PFVHYLNTFS SKEPQRGMGF MPKRGLDVSK CEIARFYKLH ERKCEPIIMT VPRKSDLFQD DLYPDTPGPE PALEADEWLS GQDAEPVLIS LRDGYVPPKH RELRVTKRNI LDVRPPSGPR RSQSASDAPL SQQHTLETLL EEIKALRERV QAQEQRITAL ENMLCELVDG TD
预测分子量	kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于CORO6重组蛋白的3篇参考文献示例(注：部分内容基于领域知识模拟，具体文献需通过数据库核实)：

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1. **文献名称**: "Characterization of Coronin 6 as a regulator of actin cytoskeleton dynamics"

**作者**: Müller A, et al.

**摘要**: 研究报道了CORO6重组蛋白在原核系统中的表达与纯化，证实其通过调控肌动蛋白聚合参与细胞迁移过程，并揭示了其与Arp2/3复合物的相互作用机制。

2. **文献名称**: "CORO6重组蛋白在肺癌细胞侵袭中的功能研究"

**作者**: Li X, et al.

**摘要**: 通过构建CORO6重组蛋白并转染肺癌细胞，发现其过表达显著抑制肿瘤细胞侵袭能力，提示其可能通过Wnt/β-catenin通路调控EMT过程。

3. **文献名称**: "Structural insights into the oligomerization of Coronin 6 by cryo-EM"

**作者**: Sharma R, et al.

**摘要**: 利用冷冻电镜解析CORO6重组蛋白的三维结构，发现其N端WD40结构域介导多聚化，为理解其参与免疫突触形成的分子机制提供结构基础。

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建议通过 **PubMed** 或 **Google Scholar** 检索关键词 "CORO6 recombinant protein" 或 "Coronin 6 expression" 获取最新文献。如需具体文献指导，请补充研究背景或应用场景。

背景信息

**Background of CORO6 Recombinant Protein**

Coronin family proteins are evolutionarily conserved regulators of cytoskeletal dynamics, primarily involved in cell migration, vesicle trafficking, and immune responses. CORO6 (coronin-6), a member of this family, is less characterized compared to its well-studied homologs like coronin-1A (CORO1A). Structurally, CORO6 contains WD40 repeat domains, which mediate protein-protein interactions, and a unique coiled-coil region, suggesting roles in scaffolding or signal transduction.

While CORO1A is critical in immune cell function, CORO6 is hypothesized to play distinct roles in non-immune tissues. Studies indicate its expression in the brain, kidney, and reproductive organs, implicating potential involvement in neurodevelopment, organogenesis, or cellular homeostasis. Notably, CORO6 has been linked to ciliary function in renal cells, with dysregulation associated with ciliopathies—a class of disorders affecting motile and sensory cilia.

Recombinant CORO6 protein is produced using heterologous expression systems (e.g., *E. coli* or mammalian cells) to enable functional studies. Its purification typically involves affinity chromatography, ensuring high purity for downstream applications like antibody generation, binding assays, or structural analysis. Research using recombinant CORO6 aims to clarify its interaction partners, such as actin-related proteins or signaling molecules, and its regulatory mechanisms in cytoskeletal remodeling.

Emerging evidence also suggests CORO6's relevance in disease contexts. For instance, aberrant CORO6 expression has been observed in certain cancers, though its role as an oncogene or tumor suppressor remains debated. Additionally, genetic variants near the *CORO6* locus have been tentatively associated with neurodevelopmental disorders, prompting interest in its neural functions.

Overall, CORO6 recombinant protein serves as a vital tool for unraveling the molecular basis of its biological activities, with implications for understanding developmental defects, ciliopathies, and cancer mechanisms. Further studies are needed to define its precise physiological roles and therapeutic potential.