Recombinant Human TES protein

中文名： 测试素(TES)重组蛋白
别名： TES；Testin

货号: PA1000-4249

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>90%SDS-PAGE.
种属	Human
靶点	TES
Uniprot No	Q9UGI8
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	1-421aa
氨基酸序列	MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
预测分子量	kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是3篇与TES重组蛋白相关的文献摘要示例：

1. **文献名称**：*TES is a novel focal adhesion protein with a role in cell proliferation*

**作者**：Chimaiyen, C. et al.

**摘要**：研究首次成功在大肠杆菌中重组表达了TES蛋白的N端结构域，证实其通过抑制整合素信号通路抑制肿瘤细胞增殖，为TES作为抑癌蛋白机制提供证据。

2. **文献名称**：*Recombinant TES protein modulates cell migration via LIM domain interactions*

**作者**：Faralli, H. et al.

**摘要**：通过杆状病毒系统表达全长TES重组蛋白，发现其通过LIM结构域与zyxin蛋白相互作用，调控细胞骨架重组并抑制乳腺癌细胞迁移能力。

3. **文献名称**：*Structural characterization of the tumor suppressor TES through recombinant expression*

**作者**：Bell, R. et al.

**摘要**：采用哺乳动物表达系统获得可溶性TES重组蛋白，通过X射线晶体学解析其三维结构，揭示其独特的LIM结构域排列方式与抑癌功能的相关性。

注：以上文献信息为模拟示例，实际文献需通过PubMed/Web of Science检索确认。TES(Testin)是已知的细胞骨架相关抑癌蛋白，其重组表达研究多集中于结构功能分析和肿瘤治疗机制探索。

背景信息

**Background of TES Recombinant Protein**

TES (Testis-derived EGF-like and Sperm-associated antigen-related), also known as TES or TES1. is a cytoskeletal protein encoded by the *TES* gene. Initially identified in testis tissue, TES is broadly expressed in various human tissues and plays a critical role in cell adhesion, motility, and signaling. Structurally, TES contains multiple functional domains, including a conserved LIM domain and a proline-rich region, enabling interactions with other proteins such as zyxin, mena, and actin-binding proteins. These interactions position TES as a scaffold protein involved in regulating cytoskeletal dynamics and focal adhesion complexes.

The *TES* gene is located on chromosome 7q31.2. a genomic region frequently associated with tumor suppressor activity. TES expression is often downregulated or silenced in multiple cancers, including breast, lung, and colorectal carcinomas, primarily due to promoter hypermethylation. Functional studies reveal that TES acts as a tumor suppressor by inhibiting cell proliferation, migration, and invasion. It modulates pathways like Wnt/β-catenin signaling and suppresses epithelial-mesenchymal transition (EMT), contributing to its anti-metastatic properties.

Recombinant TES protein is engineered using expression systems (e.g., *E. coli* or mammalian cells) to produce purified, functional TES for research. Its applications include studying tumorigenesis mechanisms, validating TES-mediated pathways, and exploring therapeutic strategies to restore TES activity in cancers. Additionally, recombinant TES serves as a tool for identifying binding partners and evaluating its role in tissue development and homeostasis. Ongoing research aims to harness TES's tumor-suppressive functions for diagnostics or targeted cancer therapies.