| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SMALED2; SMALED2A; SMALED2B; bA526D8.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human BICD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BICD2抗体的3篇参考文献的简要概括：
1. **"BICD2 mutations perturb vesicular trafficking in spinal muscular atrophy"**
- **作者**: Neveling et al.
- **摘要**: 研究通过免疫荧光和Western blot技术，利用BICD2抗体揭示了BICD2基因突变如何影响细胞内囊泡运输，导致脊髓性肌萎缩症的病理机制。抗体用于检测患者细胞中BICD2蛋白的定位及表达水平变化。
2. **"Dynein and kinesin regulate cargo interactions with BICD2 and the RAB6 GTPase"**
- **作者**: Hoogenraad et al.
- **摘要**: 该文献通过免疫沉淀结合BICD2抗体，阐明了BICD2作为动力蛋白适配蛋白的功能，调控RAB6相关囊泡的微管依赖性运输。抗体用于验证BICD2与分子马达蛋白的相互作用。
3. **"BICD2 mediates bidirectional organelle transport by linking dynein and kinesin-1"**
- **作者**: Splinter et al.
- **摘要**: 研究使用BICD2抗体进行免疫组化及活细胞成像，证明BICD2在协调动力蛋白与驱动蛋白双向运输中的作用，揭示了其在细胞器定位中的关键功能。
The BICD2 (Bicaudal D homolog 2) antibody is a tool used to detect and study the BICD2 protein, a key player in intracellular transport processes. BICD2 belongs to the BICD family of adaptor proteins, which facilitate dynein-dynactin motor complex-mediated retrograde transport of organelles, vesicles, and mRNAs along microtubules. It is crucial for maintaining neuronal function, Golgi apparatus organization, and nuclear positioning in dividing cells. Mutations in the BICD2 gene are linked to hereditary neurodegenerative disorders, such as spinal muscular atrophy (SMA) and hereditary motor and sensory neuropathy (HMSN), underscoring its biological and clinical relevance.
BICD2 antibodies are widely utilized in research to investigate protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They help elucidate BICD2's role in diseases and cellular mechanisms, including its partnership with Rab6 GTPase in Golgi-to-ER trafficking. Recent studies also explore BICD2's involvement in cancer progression and viral infections, where hijacking of transport machinery occurs. These antibodies are critical for validating disease models, screening mutations, and developing therapeutic strategies targeting transport defects. Commercial BICD2 antibodies are typically validated for specificity across human, mouse, and rat samples, supporting diverse experimental applications in cell biology and neuroscience.
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