| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MIST1; BHLHB8 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human BHLHA15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BHLHA15抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *BHLHA15 is required for the maintenance of pancreatic acinar cells and plays a role in digestive enzyme regulation*
**作者**: Shi, G., et al.
**摘要**: 该研究利用BHLHA15抗体通过免疫组化和Western blot验证了BHLHA15在小鼠胰腺腺泡细胞中的特异性表达，并发现其缺失导致细胞分化异常及消化酶分泌功能受损。
2. **文献名称**: *MIST1 (BHLHA15) regulates secretory cell identity in gastrointestinal epithelium*
**作者**: Mills, J.C., et al.
**摘要**: 通过BHLHA15抗体的免疫荧光分析，研究发现BHLHA15在胃肠道分泌细胞分化中起关键作用，其表达缺失导致细胞极性改变和分泌颗粒形成缺陷。
3. **文献名称**: *BHLHA15 promotes tumor progression in gastric cancer through transcriptional activation of oncogenic pathways*
**作者**: Wang, Y., et al.
**摘要**: 该研究利用BHLHA15抗体进行免疫沉淀和ChIP-seq实验，揭示BHLHA15通过调控Wnt/β-catenin通路相关基因转录，促进胃癌细胞侵袭和转移。
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*注：以上文献为示例，实际引用时需核对真实发表信息。建议通过PubMed或Google Scholar以“BHLHA15 antibody”或“MIST1 antibody”为关键词检索最新研究。*
The BHLHA15 antibody targets the BHLHA15 protein, a member of the basic helix-loop-helix (bHLH) family of transcription factors. BHLHA15. also known as MIST1 (Muscle, Intestine, and Stomach expression 1), plays a critical role in regulating cell differentiation and maintaining secretory cell identity, particularly in exocrine and endocrine tissues. It is essential for the development and function of secretory cells in organs such as the pancreas, salivary glands, and gastrointestinal tract. Dysregulation of BHLHA15 has been implicated in diseases like pancreatic insufficiency, diabetes, and certain cancers, including neuroendocrine tumors.
The BHLHA15 antibody is a valuable tool for detecting and studying the expression, localization, and function of BHLHA15 in research settings. It is commonly used in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) to analyze tissue-specific protein distribution and quantify expression levels. Researchers utilize this antibody to investigate BHLHA15's role in cellular differentiation pathways, its interaction with other regulatory proteins, and its potential as a biomarker or therapeutic target in diseases. Validated for specificity and sensitivity in various species and sample types, the antibody aids in elucidating molecular mechanisms underlying secretory cell biology and pathology.
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