Rabbit Polyclonal BCL2L2 Antibody

The BCL2L2 antibody targets the BCL2-like 2 protein (BCL-W), encoded by the *BCL2L2* gene, a member of the BCL-2 family of apoptosis-regulating proteins. BCL-W shares structural homology with anti-apoptotic BCL-2 family members, such as BCL-2 and BCL-XL, and functions to inhibit programmed cell death by binding pro-apoptotic proteins (e.g., BAX, BAK) and preventing mitochondrial outer membrane permeabilization. It plays critical roles in cell survival, particularly in specific tissues like the testes, placenta, and stem cells. Dysregulation of BCL-W expression is implicated in cancer, where its overexpression is linked to tumor progression, chemoresistance, and poor prognosis. Antibodies against BCL-W are essential tools in research for detecting protein expression via techniques like Western blot, immunohistochemistry, and flow cytometry. They help elucidate BCL-W's role in apoptosis, cellular homeostasis, and disease mechanisms. Additionally, these antibodies support therapeutic development, as targeting BCL-W (e.g., with BH3 mimetics) may enhance cancer cell sensitivity to apoptosis. Validation of BCL2L2 antibodies requires specificity testing due to high homology among BCL-2 family members. Understanding BCL-W's context-dependent functions remains an active area in oncology and cell biology research.