Rabbit Polyclonal NKX3-2 Antibody

The NKX3-2 antibody is a tool used to detect the NKX3-2 protein, a transcription factor encoded by the NKX3-2 gene (also known as Bapx1). This gene belongs to the NKX family of homeodomain-containing proteins, which play critical roles in embryonic development, particularly in skeletal and cartilage formation. NKX3-2 is essential for axial patterning, chondrogenesis, and the development of specific structures like the vertebral column and jaw. Dysregulation of NKX3-2 has been linked to skeletal disorders, such as spondylo-megaepiphyseal-metaphyseal dysplasia, and its expression is often altered in certain cancers. The antibody, typically produced in rabbits or mice using immunogenic peptides or recombinant proteins, enables researchers to study NKX3-2's expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It has been pivotal in elucidating NKX3-2's role in developmental biology, disease mechanisms, and potential therapeutic targets. Commercial NKX3-2 antibodies are often validated for specificity and sensitivity, though optimization may be required for specific experimental conditions. Its applications span developmental studies, cancer research, and genetic disorder investigations, making it a valuable resource for understanding transcriptional regulation in health and disease.