| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IMD60; BTBD25 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human BACH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BACH2抗体的3篇参考文献(虚构示例，仅供参考)：
1. **文献名称**: *BACH2 regulates T cell immunity by controlling chromatin accessibility*
**作者**: Roychoudhuri R, et al.
**摘要**: 研究通过BACH2特异性抗体进行ChIP-seq分析，揭示了BACH2通过调控染色质可及性抑制效应T细胞分化，维持调节性T细胞功能，从而影响免疫稳态。
2. **文献名称**: *BACH2 deficiency leads to abnormal B cell development and autoimmunity*
**作者**: Tsukumo SI, et al.
**摘要**: 利用BACH2抗体进行Western blot和免疫组化实验，发现BACH2基因敲除小鼠的B细胞发育受损，导致自身抗体产生和系统性自身免疫疾病表型。
3. **文献名称**: *BACH2 suppresses oxidative stress-induced apoptosis in hematopoietic cells*
**作者**: Sasaki M, et al.
**摘要**: 通过BACH2抗体检测蛋白表达，证实BACH2通过结合抗氧化反应元件(ARE)调控下游靶基因，保护造血干细胞免受氧化应激损伤。
4. **文献名称**: *BACH2 mutations impair immune tolerance in human autoimmune diseases*
**作者**: Ramsdell F, et al.
**摘要**: 基于BACH2抗体的流式细胞术分析，发现携带BACH2突变的患者外周血单核细胞中BACH2表达显著降低，导致调节性T细胞功能缺陷，与类风湿性关节炎等疾病相关。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed并核对原文。)
BACH2 (BTB and CNC homology 1. basic leucine zipper transcription factor 2) is a transcription regulator belonging to the basic leucine zipper (bZIP) protein family. It plays a critical role in immune system regulation, particularly in the development and differentiation of B and T lymphocytes. BACH2 is involved in orchestrating oxidative stress responses and maintaining immune homeostasis by repressing or activating target genes. It acts as a tumor suppressor in certain cancers and is implicated in autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis) and allergic disorders (e.g., asthma) due to its regulatory effects on immune cell function.
BACH2 antibodies are essential tools for studying its expression, localization, and interaction partners. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate BACH2's role in gene regulation, immune tolerance, and disease mechanisms. Research highlights its dual functionality: promoting lymphocyte maturation while suppressing premature activation, depending on cellular context.
Studies of BACH2 antibodies have advanced understanding of its structural domains (e.g., BTB domain for protein interactions, bZIP for DNA binding) and its collaboration with partners like MAF oncoproteins. Dysregulation of BACH2 is linked to immune dysfunctions and cancer progression, making it a potential therapeutic target or biomarker. Ongoing research focuses on its epigenetic regulation and tissue-specific roles in health and disease.
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