Rabbit Polyclonal CEP131 Antibody

The CEP131 antibody is a research tool used to detect and study the centrosomal protein 131 (CEP131), also known as AZI1 or centrosome and mitotic spindle-associated protein. CEP131 is a key component of centriolar satellites, dynamic structures surrounding centrosomes that regulate centrosome maturation, ciliogenesis, and microtubule organization. It plays a role in maintaining genomic stability, cell cycle progression, and primary cilium assembly. Dysregulation of CEP131 has been implicated in cancers, including breast cancer and neuroblastoma, where its overexpression correlates with tumor aggressiveness and poor prognosis. The antibody is commonly employed in techniques like immunofluorescence, Western blotting, and immunoprecipitation to visualize CEP131's subcellular localization, assess expression levels, and investigate interactions with other centrosomal proteins. Researchers use it to explore mechanisms underlying ciliopathies, chromosomal instability, and cancer biology. Commercial CEP131 antibodies are typically raised in rabbits or mice against specific epitopes of the human protein, with validation in knock-out cell lines to confirm specificity. Its applications span basic cell biology research, clinical studies on cilia-related disorders, and oncological investigations targeting centrosome amplification in malignancies.