| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | L40; CEP52; RPL40; HUBCEP52 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human UBA52 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBA52抗体的模拟参考文献示例(实际文献需通过学术数据库检索确认)：
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1. **文献名称**: "Characterization of UBA52-Specific Antibodies for Ubiquitin-Proteasome System Studies"
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对UBA52蛋白的特异性多克隆抗体，用于检测细胞内泛素-核糖体融合蛋白的表达。通过免疫印迹和免疫荧光实验，证明该抗体在多种细胞系中具有高灵敏度和特异性，为研究UBA52在蛋白质降解中的作用提供了工具。
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2. **文献名称**: "UBA52 Antibody Application in Autophagy and Cancer Research"
**作者**: Chen L, et al.
**摘要**: 文章利用UBA52单克隆抗体探究其在自噬调控中的功能。研究发现UBA52通过泛素化修饰影响自噬相关蛋白稳定性，抗体在组织样本中的表达水平与癌症患者的预后显著相关，提示其作为生物标志物的潜力。
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3. **文献名称**: "Cross-Reactivity Analysis of Anti-UBA52 Antibodies in Autoimmune Diseases"
**作者**: Tanaka K, et al.
**摘要**: 研究评估了UBA52抗体在系统性红斑狼疮(SLE)患者中的交叉反应性，发现部分患者血清中的自身抗体与UBA52表位存在交叉反应，可能参与自身免疫病理过程，为疾病机制研究提供新方向。
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4. **文献名称**: "Development of a Novel ELISA Using UBA52 Antibody for Ubiquitin Quantification"
**作者**: Müller R, et al.
**摘要**: 本研究建立了一种基于UBA52抗体的ELISA检测方法，用于定量分析细胞裂解液中的泛素水平。该方法在多种病理模型中得到验证，为泛素化动态监测提供了高特异性工具。
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**注意**：以上为模拟示例，实际文献需通过 **PubMed**、**Google Scholar** 或 **Web of Science** 等平台检索关键词如“UBA52 antibody”、“UBA52 ubiquitin antibody”获取。若需具体文献，建议结合研究领域进一步筛选。
**Background of UBA52 Antibody**
UBA52. a ubiquitin-ribosomal fusion protein, encodes ubiquitin and the 60S ribosomal protein L40. Ubiquitin is a highly conserved regulatory protein critical for protein degradation via the ubiquitin-proteasome system (UPS), which governs cellular processes like cell cycle progression, DNA repair, and stress response. The UBA52 gene produces a precursor protein that is post-translationally processed to release ubiquitin and the functional ribosomal protein L40. This unique fusion mechanism ensures coordinated synthesis of ubiquitin and ribosomal components, linking protein turnover and ribosome biogenesis.
Antibodies targeting UBA52 are essential tools for studying its dual role in ubiquitin-dependent pathways and ribosome assembly. They help detect UBA52 expression levels, localization, and processing in various tissues or experimental models. Research applications include investigating dysregulation in cancers, neurodegenerative diseases, or conditions linked to UPS dysfunction. Such antibodies are often validated in techniques like Western blotting, immunohistochemistry, and immunofluorescence.
Understanding UBA52’s biology through specific antibodies provides insights into cellular homeostasis, disease mechanisms, and potential therapeutic targets modulating ubiquitin or ribosomal pathways. Its conservation across species also makes it a valuable marker in comparative studies.
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