| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MCOPS11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human VAX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VAX1抗体的3篇示例文献(注：文献信息为假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: *"Role of VAX1 in murine optic nerve development"*
**作者**: Bertuzzi, S., & Hébert, R. (2002)
**摘要**: 研究VAX1在小鼠视神经发育中的作用，通过VAX1抗体检测其在前脑区域的表达模式，发现其缺失导致视网膜轴突导向异常。
2. **文献名称**: *"VAX1 gene mutations and their association with cleft lip/palate"*
**作者**: Hoeflich, J., et al. (2008)
**摘要**: 分析VAX1基因突变与唇腭裂的关联，利用VAX1抗体进行胚胎组织免疫染色，揭示其在面部发育中的关键调控作用。
3. **文献名称**: *"VAX1 regulates retinal progenitor cell differentiation"*
**作者**: Zhang, Y., et al. (2015)
**摘要**: 通过VAX1抗体阻断实验，证明VAX1通过调控Sonic hedgehog信号通路影响视网膜祖细胞的分化过程。
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如需实际文献，建议在 **PubMed** 或 **Google Scholar** 中搜索关键词 `VAX1 antibody` 或 `VAX1 immunohistochemistry`，并筛选近年研究。
The VAX1 antibody is a tool used to detect the ventral anterior homeobox 1 (VAX1) protein, a transcription factor encoded by the VAX1 gene. VAX1 belongs to the homeobox gene family, which plays critical roles in embryonic development, particularly in the formation of the eyes, forebrain, and craniofacial structures. Studies have linked VAX1 to the regulation of optic nerve and pituitary gland development, as well as facial patterning. Mutations or dysregulation of VAX1 are associated with congenital defects such as microphthalmia, cleft palate, and holoprosencephaly, highlighting its importance in early morphogenesis.
VAX1 antibodies are widely employed in research to investigate neural development, congenital anomalies, and genetic disorders. They enable localization and quantification of VAX1 protein expression in tissues or cells via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence. These antibodies are crucial for studying VAX1's interaction with signaling pathways (e.g., Sonic Hedgehog) and its role in stem cell differentiation or tissue regeneration. Validated antibodies undergo specificity tests, including knockout controls, to ensure accurate detection. As VAX1 research expands into neurodevelopmental disorders and regenerative medicine, reliable antibodies remain essential for unraveling its molecular mechanisms and therapeutic potential.
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