Rabbit Polyclonal VAMP4 Antibody

VAMP4 (vesicle-associated membrane protein 4) is a member of the SNARE protein family that mediates intracellular vesicle trafficking and membrane fusion. Primarily localized to the trans-Golgi network and endosomes, it plays a critical role in regulating secretory pathways, lysosomal sorting, and synaptic vesicle recycling. VAMP4 antibodies are immunological tools designed to detect and study this protein’s expression, localization, and function. These antibodies are typically generated using immunogenic peptides or recombinant VAMP4 fragments as antigens, often in hosts like rabbits or mice. Validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation, they enable researchers to investigate VAMP4’s interaction with other SNARE proteins (e.g., syntaxins) and its involvement in neurological disorders, endocrine secretion, or cancer metastasis. Recent studies highlight VAMP4’s relevance in neurodegenerative diseases like Alzheimer’s, where disrupted vesicle transport contributes to pathology, and in diabetes, where insulin granule exocytosis is impaired. Commercial VAMP4 antibodies are often characterized for species reactivity (human, mouse, rat) and tested for specificity using knockout controls. Proper validation remains essential due to potential cross-reactivity with homologous VAMP isoforms (e.g., VAMP1-3).