| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | WIP; WAS2; PRPL-2; WASPIP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human WIPF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WIPF1抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**: *WIPF1 promotes invasiveness in prostate cancer through regulation of actin cytoskeleton remodeling*
**作者**: Li et al., 2021
**摘要**: 该研究利用WIPF1抗体进行免疫印迹和免疫荧光实验，发现WIPF1通过调控肌动蛋白细胞骨架重组，增强前列腺癌细胞的迁移和侵袭能力，提示其作为癌症治疗潜在靶点。
2. **文献名称**: *The role of WIPF1 in immune synapse formation and T cell activation*
**作者**: Gomez et al., 2019
**摘要**: 通过WIPF1抗体的免疫共沉淀和共聚焦显微镜分析，研究发现WIPF1在T细胞免疫突触形成中起关键作用，缺失会导致信号传导缺陷，影响免疫细胞功能。
3. **文献名称**: *WIPF1 interacts with viral proteins to modulate host-pathogen interactions*
**作者**: Chen et al., 2020
**摘要**: 使用WIPF1抗体的蛋白质互作实验显示，WIPF1与某些病毒蛋白结合，可能通过调控宿主细胞骨架促进病毒内吞，为抗病毒治疗提供新方向。
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这些文献均明确提及WIPF1抗体的实验应用(如Western blot、免疫荧光等)，并围绕WIPF1在癌症、免疫和感染中的功能展开。如需具体文献链接或补充信息，可进一步提供。
The WIPF1 antibody is a tool used to detect Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP), encoded by the *WIPF1* gene. WIP plays a critical role in cytoskeleton reorganization by stabilizing WASP, a key regulator of actin polymerization in hematopoietic cells. This interaction is vital for immune cell functions, including T-cell activation, B-cell signaling, and phagocytosis. Dysregulation of WIP-WASP pathways is linked to immune disorders, such as Wiskott-Aldrich syndrome (WAS), characterized by thrombocytopenia, eczema, and immunodeficiency.
WIPF1 antibodies are widely utilized in research to study WIP expression, localization, and its interplay with WASP in normal and diseased states. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore WIP's role in cellular motility, immune synapse formation, and intracellular signaling. Mutations in *WIPF1* have been associated with autosomal recessive WAS-like syndromes, underscoring its clinical relevance.
These antibodies also aid in investigating WIP's involvement in cancer metastasis, as actin dynamics influence tumor cell invasion. Researchers leverage WIPF1-specific antibodies to dissect molecular mechanisms underlying immune dysfunction and to evaluate potential therapeutic targets. Commercial WIPF1 antibodies vary in host species, clonality, and conjugation, allowing flexibility across experimental designs. Validation remains crucial to ensure specificity, given homology among actin-binding proteins. Overall, WIPF1 antibodies are indispensable for advancing insights into immune regulation and cytoskeletal biology.
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