Rabbit Polyclonal XYLT1 Antibody

XYLT1 (Xylosyltransferase 1) is a key enzyme in proteoglycan biosynthesis, catalyzing the initial step of glycosaminoglycan (GAG) chain attachment to core proteins by transferring xylose residues to specific serine residues. This process is critical for extracellular matrix (ECM) assembly, cell-matrix interactions, and signaling pathways involved in tissue development, homeostasis, and disease. XYLT1 antibodies are immunological tools designed to detect and quantify XYLT1 protein expression in research applications, including Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are particularly valuable in studies exploring ECM remodeling disorders, such as fibrosis, osteoarthritis, and cancer metastasis, where altered XYLT1 activity correlates with pathological ECM stiffness and tumor progression. Additionally, XYLT1 mutations are linked to rare connective tissue disorders like Desbuquois dysplasia, driving interest in its functional characterization. Commercial XYLT1 antibodies are typically raised against specific epitopes (e.g., human XYLT1 amino acid residues 628-827) and validated for species cross-reactivity (human, mouse, rat). Recent research also implicates XYLT1 in TGF-β signaling activation and mechanotransduction pathways, expanding its relevance in developmental biology and regenerative medicine. Proper antibody validation using knockout controls remains essential due to potential cross-reactivity with XYLT2. a homologous isoform with overlapping functions.