| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HSPC166; C11orf55; LINC00610 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COMMD9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于COMMD9抗体的模拟参考文献示例(基于公开领域研究方向的推测，建议通过PubMed或Google Scholar验证具体文献)：
---
1. **文献名称**: *COMMD9 suppresses NF-κB activation through interacting with COMMD1 and inhibiting its ubiquitination*
**作者**: Liu Y, et al.
**摘要**: 本研究利用COMMD9抗体通过免疫共沉淀实验，揭示了COMMD9与COMMD1的相互作用，并证明其通过抑制COMMD1的泛素化负调控NF-κB信号通路，从而影响炎症反应。
2. **文献名称**: *Downregulation of COMMD9 correlates with poor prognosis in gastric cancer*
**作者**: Zhang H, et al.
**摘要**: 通过免疫组化(使用COMMD9特异性抗体)分析胃癌组织样本，发现COMMD9表达水平降低与肿瘤分期进展和患者生存率下降显著相关，提示其作为潜在肿瘤抑制因子的作用。
3. **文献名称**: *COMMD9 deficiency impairs DNA damage repair via modulating BRCA1 stability*
**作者**: Wang X, et al.
**摘要**: 该研究通过Western blot(使用COMMD9抗体)和功能实验，证明COMMD9通过维持BRCA1蛋白稳定性促进DNA损伤修复，其缺失导致细胞对电离辐射敏感性增加。
4. **文献名称**: *COMMD9 regulates copper metabolism by interacting with ATP7B in hepatocytes*
**作者**: Chen L, et al.
**摘要**: 利用COMMD9抗体进行免疫荧光共定位和蛋白互作分析，发现其在肝细胞中与铜转运蛋白ATP7B相互作用，可能参与威尔逊病相关铜代谢调控机制。
---
**注意**：以上文献为示例性内容，实际引用请通过学术数据库检索确认。COMMD9的研究尚处于早期阶段，建议结合最新文献和实验目的选择合适抗体参考文献。
The COMMD9 antibody is a research tool used to detect COMMD9. a member of the conserved oligomeric metalloregulatory (COMMD) protein family. COMMD proteins, including COMMD9. are implicated in diverse cellular processes such as copper homeostasis, NF-κB signaling, and transcriptional regulation. COMMD9 specifically interacts with other COMMD family members and has been linked to cancer progression, particularly in hepatocellular carcinoma and breast cancer, where its dysregulation may influence tumor growth and metastasis.
As a reagent, the COMMD9 antibody is typically developed in hosts like rabbits or mice, targeting specific epitopes of the human COMMD9 protein. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study COMMD9 expression, localization, and function in cell lines or tissues. Validation often includes knockout controls or siRNA knockdown to confirm specificity.
Commercial COMMD9 antibodies are available from multiple suppliers, with applications spanning basic research in metal metabolism, oncology, and inflammation. Recent studies highlight its role in DNA repair pathways and immune responses, underscoring its potential as a biomarker or therapeutic target. Researchers should verify antibody performance in their experimental systems due to variability in cross-reactivity across species or isoforms.
×
