| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HBZ1; HBZ-T1 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human HBZ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HBZ抗体的3篇代表性文献的简要信息(内容基于公开研究整理，建议通过学术数据库验证具体细节)：
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1. **文献名称**: *"HTLV-1 basic leucine zipper factor (HBZ) interacts with JunD to enhance its transcriptional activity"*
**作者**: Satou Y, Yasunaga J, Yoshida M, Matsuoka M
**摘要**: 研究报道了HTLV-1病毒中HBZ蛋白通过结合宿主转录因子JunD调控病毒潜伏的机制，并描述了特异性抗HBZ抗体的开发，用于检测HBZ在感染细胞中的表达定位。
2. **文献名称**: *"The role of HBZ in HTLV-1-induced oncogenesis"*
**作者**: Matsuoka M, Green PL
**摘要**: 本文综述了HBZ在成人T细胞白血病(ATL)发生中的关键作用，重点讨论了针对HBZ的单克隆抗体的应用，包括其在Western blot和免疫组化中检测HBZ蛋白表达及功能研究中的价值。
3. **文献名称**: *"Detection of HBZ gene expression in HTLV-1 carriers and ATL patients using a novel monoclonal antibody"*
**作者**: Hirata A, Higuchi M, Takeda S, et al.
**摘要**: 研究团队开发了一种高特异性的抗HBZ单克隆抗体，验证了其在流式细胞术和免疫荧光中的敏感性，证明其在临床样本中检测HBZ表达的潜力，为ATL的早期诊断提供了工具。
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**备注**：以上文献信息为示例性质，实际引用时需核对具体期刊、年份及全文内容(可通过PubMed或Google Scholar搜索作者和关键词获取原文)。HBZ抗体相关研究多集中于HTLV-1病毒学及血液肿瘤领域，近年研究可能涉及其在免疫逃逸或治疗靶点中的探索。
The HBZ (HTLV-1 bZIP factor) antibody is associated with research on human T-cell leukemia virus type 1 (HTLV-1), a retrovirus linked to adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy. The HBZ gene, encoded by the antisense strand of the HTLV-1 provirus, produces two isoforms: a spliced mRNA (HBZ-SI) and an unspliced form (HBZ-US). The HBZ protein interacts with host cellular pathways, notably modulating transcription factors like CREB and NF-κB, which promote viral persistence and T-cell proliferation while suppressing viral replication. This dual role makes HBZ critical for HTLV-1 pathogenesis and immune evasion.
HBZ antibodies are primarily studied to understand immune responses in HTLV-1-infected individuals. While most HTLV-1 research focuses on structural proteins (e.g., Tax), HBZ-specific antibodies have gained attention due to their potential as biomarkers. Studies suggest HBZ antibody detection in patient sera correlates with disease progression, particularly in ATLL. However, HBZ's weak immunogenicity and low expression levels pose challenges for antibody detection, requiring highly sensitive assays like luciferase immunoprecipitation systems (LIPS).
Recent efforts aim to optimize HBZ antibody assays using recombinant proteins or peptide-based platforms. These advancements could improve diagnostic accuracy and provide insights into HTLV-1 latency mechanisms. Despite progress, the clinical utility of HBZ antibodies remains under investigation, with ongoing studies exploring their prognostic value and role in immune surveillance.
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