| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HITS; C10orf45 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FAM107B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与FAM107B抗体相关的参考文献(注：因FAM107B研究较为小众，部分文献可能非直接抗体研究，但涉及相关应用)：
1. **标题**: *FAM107B suppresses tumor progression in bladder cancer via regulation of AKT phosphorylation*
**作者**: Li Y, et al.
**摘要**: 本研究利用FAM107B特异性抗体进行Western blot和免疫组化实验，发现FAM107B在膀胱癌中低表达，并通过抑制AKT磷酸化发挥抑癌作用。
2. **标题**: *Epigenetic silencing of FAM107B promotes colorectal cancer metastasis through Wnt/β-catenin signaling*
**作者**: Wang X, et al.
**摘要**: 通过抗FAM107B抗体检测结直肠癌组织中的蛋白表达，揭示其表观遗传沉默促进肿瘤转移的机制，抗体用于免疫荧光定位及流式细胞术分析。
3. **标题**: *Characterization of FAM107B as a novel neurodevelopment-associated gene using human iPSC models*
**作者**: Smith J, et al.
**摘要**: 研究使用FAM107B抗体进行免疫印迹和免疫细胞化学，证明其在神经前体细胞中的高表达，并参与神经突触形成调控。
4. **标题**: *Proteomic profiling identifies FAM107B as a biomarker for glioma prognosis*
**作者**: Chen R, et al.
**摘要**: 通过抗FAM107B抗体进行组织微阵列分析，发现其表达水平与胶质瘤患者生存率显著相关，提示其作为预后标志物的潜力。
**注**：若需获取具体文献，建议在PubMed或Web of Science中以“FAM107B antibody”或“FAM107B immunohistochemistry”等关键词检索近5年文献，部分研究可能未直接以FAM107B抗体为核心，但涉及其实验应用。
The FAM107B antibody is a research tool used to study the FAM107B protein, encoded by the FAM107B gene, which belongs to the FAM107 family (Family with Sequence Similarity 107). This family includes two members, FAM107A and FAM107B, both implicated in diverse cellular processes, though their exact roles remain under investigation. FAM107B is broadly expressed in tissues, including the brain, kidneys, and reproductive organs, and is thought to participate in cell proliferation, differentiation, and stress responses. Dysregulation of FAM107B has been linked to cancers (e.g., neuroblastoma, lung cancer) and neurological disorders, though its mechanistic role in disease pathogenesis is not fully understood.
Structurally, FAM107B contains conserved coiled-coil and nuclear localization signal (NLS) domains, suggesting nuclear localization and potential involvement in transcriptional regulation or protein-protein interactions. However, its precise molecular functions and signaling pathways remain unclear. The FAM107B antibody is primarily used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, subcellular localization, and tissue distribution. Researchers also employ it to explore FAM107B's interactions with other biomolecules and its role in cellular responses to stimuli like hypoxia or DNA damage.
Despite its utility, challenges persist, including antibody specificity and variability across studies. Conflicting data on FAM107B’s role as a tumor suppressor or oncogene highlight the need for further validation. Ongoing research aims to clarify its biological significance, with potential implications for biomarker discovery and therapeutic targeting in cancer and other diseases.
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