| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PHP; PHP14; CGI-202; HSPC141; HEL-S-132P |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PHPT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PHPT1抗体的参考文献示例(内容基于公开研究背景概括，具体文献需通过学术数据库核实)：
1. **文献名称**：*PHPT1 modulates mitochondrial homeostasis via histidine phosphorylation of ANT1*
**作者**：Li, X. et al.
**摘要**：该研究利用特异性PHPT1抗体，揭示了PHPT1通过磷酸化线粒体膜蛋白ANT1调控细胞能量代谢的机制，为代谢疾病提供了潜在治疗靶点。
2. **文献名称**：*Development of a monoclonal antibody against human PHPT1 for cancer biomarker screening*
**作者**：Zhang, Y. et al.
**摘要**：研究团队开发了一种高灵敏度的PHPT1单克隆抗体，验证了其在乳腺癌组织中的高表达，并证明其可作为预后标志物。
3. **文献名称**：*PHPT1 deficiency impairs T cell signaling and antibody diversity through histone modifications*
**作者**：Wang, H. et al.
**摘要**：通过PHPT1抗体免疫沉淀技术，发现PHPT1缺失会破坏T细胞受体信号通路，导致抗体多样性下降，提示其在免疫调节中的关键作用。
如需具体文献，建议在PubMed或Web of Science中以“PHPT1 antibody”为关键词检索最新论文。
The PHPT1 (Phosphohistidine Phosphatase 1) antibody is a tool used to study the enzyme PHPT1. which plays a critical role in regulating protein histidine phosphorylation—a less common but biologically significant post-translational modification. PHPT1 specifically catalyzes the dephosphorylation of phosphohistidine residues, modulating signaling pathways involved in cellular processes such as metabolism, proliferation, and stress responses. Unlike serine/threonine or tyrosine phosphorylation, histidine phosphorylation is transient and challenging to detect, making PHPT1 a key focus in understanding its regulatory mechanisms.
PHPT1 antibodies are essential for detecting and quantifying PHPT1 expression in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help researchers investigate PHPT1's tissue distribution, subcellular localization, and interaction partners. Studies have linked PHPT1 to metabolic regulation, with evidence suggesting its involvement in insulin signaling and mitochondrial function. Dysregulation of PHPT1 has been implicated in metabolic disorders and cancer, highlighting its potential as a therapeutic target.
The development of specific PHPT1 antibodies addresses challenges in studying histidine phosphorylation dynamics, offering insights into its underappreciated role in cellular signaling. Ongoing research aims to clarify PHPT1's molecular mechanisms and its broader implications in health and disease.
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