| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | P27; ISG12; FAM14D; ISG12A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IFI27 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于IFI27抗体的3篇参考文献示例(内容为模拟虚构，仅供参考)：
1. **文献名称**：《IFI27作为丙型肝炎病毒感染的新型血清生物标志物研究》
**作者**：Zhang L, et al.
**摘要**：本研究通过ELISA检测发现，慢性丙型肝炎患者血清中IFI27蛋白水平显著升高，且与病毒载量呈正相关。使用特异性IFI27抗体的实验表明，该蛋白可作为潜在的诊断标志物及治疗靶点。
2. **文献名称**：《IFI27在COVID-19重症患者外周血单核细胞中的表达及临床意义》
**作者**：Wang Y, et al.
**摘要**：通过流式细胞术和Western blot分析，发现重症COVID-19患者单核细胞中IFI27表达显著上调。抗IFI27抗体阻断实验提示其可能通过调控炎症因子风暴影响疾病进展。
3. **文献名称**：《IFI27在乳腺癌组织中的异常表达与预后相关性分析》
**作者**：Chen H, et al.
**摘要**：采用免疫组化技术结合IFI27抗体检测乳腺癌组织样本，发现IFI27高表达与患者总生存期缩短相关，提示其可能作为三阴性乳腺癌的预后预测指标。
(注：以上文献信息为示例，实际引用请以真实出版物为准。)
The IFI27 antibody targets the interferon-alpha-inducible protein 27 (IFI27), a member of the ISG12 family encoded by the IFI27 gene. This gene is highly responsive to type I interferons (IFNs) and is upregulated during viral infections, inflammatory responses, and cellular stress. IFI27 plays a role in apoptosis, immune regulation, and antiviral defense, though its precise mechanisms remain under investigation. Studies suggest it may promote mitochondrial-dependent apoptosis by interacting with BCL-2 family proteins, influencing cell survival during infections or inflammatory conditions.
IFI27 is implicated in various diseases. Elevated expression is observed in chronic viral infections (e.g., HIV, HCV), autoimmune disorders, and cancers, including liver, breast, and lung malignancies. Its overexpression in tumors often correlates with poor prognosis, suggesting potential as a diagnostic or prognostic biomarker. In viral contexts, IFI27 may limit viral replication but could also contribute to tissue damage through excessive apoptosis.
The IFI27 antibody is widely used in research to detect protein expression in tissues or cells, aiding studies on viral pathogenesis, cancer biology, and immune responses. Commercial antibodies are validated for techniques like Western blot, immunohistochemistry, and flow cytometry. However, discrepancies in reported functions highlight the need for further research to clarify its roles and therapeutic potential. Its dual pro- and anti-inflammatory effects underscore the complexity of IFI27 in disease contexts.
×
