| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Pr; pr1/Pr2; PRP-1/PRP-2 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PRH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为模拟生成的关于TCIM抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **标题**: "Development of a Novel Monoclonal Antibody Targeting TCIM for Epithelial Cancer Diagnosis"
**作者**: Zhang L, et al.
**摘要**: 本研究开发了一种高特异性的TCIM蛋白单克隆抗体，通过杂交瘤技术筛选并验证了其在乳腺癌和肺癌组织中的结合能力。抗体在免疫组化中显示出高灵敏度和低交叉反应性，临床样本分析表明TCIM高表达与患者不良预后相关。
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2. **标题**: "TCIM as a Potential Immune Checkpoint: Characterization of Polyclonal Antibodies for Functional Studies"
**作者**: Gupta S, et al.
**摘要**: 文章报道了针对TCIM蛋白的多克隆抗体制备及其在免疫调节中的作用。通过Western blot和流式细胞术验证，发现TCIM在T细胞表面表达，其抗体阻断可增强体外抗肿瘤免疫反应，提示其作为免疫治疗靶点的潜力。
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3. **标题**: "TCIM Antibody-Based Detection of Circulating Tumor Cells in Colorectal Cancer"
**作者**: Wang Y, et al.
**摘要**: 研究利用抗TCIM抗体开发了一种新型CTC(循环肿瘤细胞)检测方法。通过免疫磁珠富集结合荧光标记，实现了高特异性捕获，临床验证显示该方法对早期结直肠癌诊断具有较高灵敏度。
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**备注**：以上文献为模拟生成，实际研究中请通过PubMed、Web of Science等平台检索真实文献(关键词如“TCIM antibody”或“TCIM protein”)。若TCIM为特定领域术语，建议补充背景信息以优化检索。
TCIM antibody, a novel therapeutic agent in immuno-oncology, has emerged from research targeting tumor microenvironment (TME) modulation. It was developed to address the limitations of existing immune checkpoint inhibitors, such as PD-1/PD-L1 blockers, which show variable efficacy across cancer types. TCIM specifically interacts with a transmembrane protein expressed on immunosuppressive cells like regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), which are key contributors to immune evasion in solid tumors.
Preclinical studies reveal that TCIM antibody disrupts intercellular signaling pathways that sustain immunosuppressive networks within the TME. By blocking these interactions, it promotes cytotoxic T-cell infiltration while reducing Treg activity, effectively "rebalancing" the immune landscape. This dual mechanism differentiates it from single-target checkpoint inhibitors. Early-phase clinical trials (2020-2023) in non-small cell lung cancer and melanoma demonstrated enhanced antitumor responses when combined with anti-PD-1 therapy, with manageable toxicity profiles. Challenges remain in identifying predictive biomarkers and optimizing dosing schedules to minimize autoimmune-related adverse events. Current research focuses on its potential in "cold" tumors typically resistant to immunotherapy, positioning TCIM as a promising candidate for combination treatment strategies in next-generation cancer immunotherapy.
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