| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TFQTL1; PRO1557; PRO2086 |
| WB Predicted band size | 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TF |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SAP130抗体的3篇参考文献示例(注：文献为虚构示例，仅用于演示格式)：
1. **文献名称**：*SAP130 mediates histone deacetylase activity in transcriptional repression*
**作者**：Johnson R, et al.
**摘要**：本研究通过免疫沉淀(使用SAP130特异性抗体)揭示了SAP130在SIN3A/HDAC复合物中的核心作用，证实其通过去乙酰化调控靶基因的转录抑制。
2. **文献名称**：*SAP130-dependent inflammasome activation in macrophages*
**作者**：Chen L, et al.
**摘要**：利用SAP130抗体进行Western blot和免疫荧光实验，证明SAP130通过结合NLRP3蛋白促进炎症小体活化，为自身免疫疾病机制提供新见解。
3. **文献名称**：*SAP130 expression correlates with poor prognosis in hepatocellular carcinoma*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化(使用商业化SAP130抗体)分析肝癌组织样本，发现SAP130高表达与患者生存期缩短相关，提示其作为潜在肿瘤标志物。
4. **文献名称**：*Structural mapping of SAP130 antigenic domains for antibody development*
**作者**：Müller S, et al.
**摘要**：通过重组蛋白表达和抗体表位筛选，鉴定了SAP130的关键抗原区域，为开发高特异性诊断抗体提供理论基础。
---
**注**：以上文献为模拟内容，实际引用请通过PubMed、Web of Science等平台以关键词“SAP130 antibody”检索最新研究。
The SAP130 (SIN3A-associated protein 130) antibody targets a core component of the SIN3 histone deacetylase (HDAC) complex, a conserved multi-protein assembly critical for transcriptional regulation. SAP130. a 130 kDa protein, was initially identified through its interaction with SIN3A, a scaffold protein that recruits HDACs to modify chromatin structure and repress gene expression. The SIN3 complex, including SAP130. plays a role in epigenetic silencing by removing acetyl groups from histones, promoting chromatin condensation and transcriptional inhibition.
SAP130 is involved in diverse cellular processes, such as cell cycle control, DNA repair, and apoptosis. It contains conserved domains facilitating protein-protein interactions, enabling recruitment of chromatin modifiers to specific genomic loci. Studies link SAP130 to developmental regulation and disease contexts, including cancer and neurological disorders, where aberrant HDAC activity contributes to pathogenesis.
Antibodies against SAP130 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like immunoprecipitation, Western blotting, and immunofluorescence to study SIN3 complex dynamics and its role in gene regulation. Research on SAP130 also explores its potential as a therapeutic target, particularly in cancers where epigenetic dysregulation drives malignancy. Its functional diversity underscores its importance in both basic biology and translational medicine.
×
