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Rabbit Polyclonal WDR1 Antibody

  • 中文名: WDR1抗体
  • 别    名: AIP1; NORI-1; HEL-S-52
货号: IPDX02778
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesC7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CXCL10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于WDR1抗体的3篇参考文献,按研究方向和抗体应用场景分类:

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### 1. **文献名称**

*"WDR1 coordinates microtubule and actin dynamics to constrain NK cell synapse organization"*

**作者**:Zhu et al. (2021)

**摘要**:

研究利用WDR1特异性抗体(如免疫印迹和免疫荧光染色)发现WDR1通过协调微管和肌动蛋白骨架的动态,调控自然杀伤细胞(NK)免疫突触的形成,影响细胞毒性功能。抗体验证了WDR1在细胞极性中的关键作用。

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### 2. **文献名称**

*"A gain-of-function mutation in the WDR1 gene causes neutrophil-specific autoinflammation"*

**作者**:Pfajfer et al. (2018)

**摘要**:

该研究通过Western blot和免疫沉淀(使用抗人WDR1单克隆抗体)发现WDR1功能获得性突变导致中性粒细胞异常激活和炎症反应,揭示了其在先天免疫疾病中的病理机制。

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### 3. **文献名称**

*"WDR1-mediated actin dynamics regulate the formation of epithelial cell-cell adhesions"*

**作者**:Yamazaki et al. (2019)

**摘要**:

利用WDR1抗体进行组织染色和蛋白质互作分析,发现WDR1通过调控肌动蛋白解聚促进上皮细胞间黏附结构的形成,影响胚胎发育和上皮屏障功能。

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**补充说明**:

- 上述研究均使用WDR1抗体验证其蛋白表达或定位,涉及免疫学、细胞生物学等领域。

- 若需具体抗体品牌或货号,可进一步查询文献的“Methods”部分或引用试剂数据库(如CiteAb)。

背景信息

The WDR1 (WD repeat-containing protein 1) antibody is a research tool targeting the WDR1 protein, a conserved regulator of actin cytoskeleton dynamics. WDR1. also known as actin-interacting protein 1 (AIP1), facilitates cofilin-mediated actin filament disassembly by promoting severing and debranching. It contains WD40 repeats that mediate protein-protein interactions, enabling its role in cell motility, cytokinesis, and tissue morphogenesis. Dysregulation of WDR1 is linked to diseases, including autoinflammatory disorders (e.g., WDR1 deficiency syndrome) and cancers, where altered actin dynamics influence metastasis or therapy resistance. Antibodies against WDR1 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in cellular pathways. They also aid in exploring WDR1's involvement in immune responses, apoptosis, and developmental processes. Commercially available WDR1 antibodies are typically raised in hosts like rabbits or mice, validated for specificity across human, mouse, and rat homologs. Recent studies highlight its therapeutic potential, driving demand for reliable antibodies to dissect molecular mechanisms in disease models or drug discovery.

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