| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CTD-binding SR-like protein RA4; SFR15; splicing factor; arginine/serine-rich 15; |
| Entrez GeneID | 57466; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SFRS15. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SFRS15抗体的3篇示例性参考文献(注：内容为模拟示例，非真实文献)：
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1. **文献名称**：*SFRS15 Antibody Development and Its Application in Tumor Profiling*
**作者**：Chen L, et al.
**摘要**：本研究报道了一种新型SFRS15单克隆抗体的开发，通过免疫印迹和免疫组化验证其特异性。实验表明，SFRS15在多种癌症组织中高表达，提示其可能作为肿瘤标志物的潜在价值。
2. **文献名称**：*Role of SFRS15 in RNA Splicing Regulation Revealed by Antibody-Based Assays*
**作者**：Smith J, et al.
**摘要**：利用特异性SFRS15抗体，研究者发现该蛋白通过调控特定mRNA剪接事件影响细胞周期进程。免疫荧光实验显示SFRS15主要定位于细胞核的剪接体复合物中。
3. **文献名称**：*SFRS15 Antibody Validation in Neurodegenerative Disease Models*
**作者**：Tanaka K, et al.
**摘要**：本文验证了SFRS15抗体在阿尔茨海默病模型中的应用，发现SFRS15表达水平与神经元突触功能异常相关，提示其在神经退行性病变中的调控作用。
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以上内容为模拟示例，实际文献需通过学术数据库检索确认。若需进一步分析SFRS15的功能或抗体应用场景，可提供更具体的研究方向。
**Background of SRSF15 Antibody**
The SRSF15 (serine/arginine-rich splicing factor 15) antibody is a research tool designed to detect and study the SRSF15 protein, a member of the serine/arginine-rich (SR) family of splicing factors. These proteins play critical roles in constitutive and alternative splicing of pre-mRNA by binding to specific RNA sequences and recruiting spliceosomal components. SRSF15 contains characteristic RS domains for protein-protein interactions and an RNA recognition motif (RRM) for RNA binding.
Research using SRSF15 antibodies has highlighted its involvement in regulating spliceosome assembly, mRNA export, and translation. Dysregulation of SRSF15 is linked to diseases such as cancer, where aberrant splicing contributes to tumor progression and metastasis. For example, SRSF15 overexpression has been observed in certain malignancies, correlating with poor prognosis.
This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SRSF15’s expression, localization, and interactions. It aids in elucidating its role in cellular processes, including stress responses and cell cycle regulation. Commercial SRSF15 antibodies are typically validated for specificity and sensitivity, often targeting unique epitopes within its RS or RRM domains.
Overall, the SRSF15 antibody serves as a vital reagent for exploring RNA metabolism mechanisms and their implications in disease, offering insights for therapeutic targeting of splicing-related disorders.
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