| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Spectrin beta chain; brain 4; Spectrin; non-erythroid beta chain 4; Beta-V spectrin |
| Entrez GeneID | 51332; |
| WB Predicted band size | 417kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SPTBN5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是几篇假设的关于SPTBN5抗体的参考文献示例(注：SPTBN5相关研究较少，实际文献可能需要根据最新数据库检索)：
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1. **标题**：*SPTBN5 regulates hepatocellular carcinoma progression via cytoskeletal remodeling*
**作者**：Zhang, Y. et al. (2020)
**摘要**：本研究利用SPTBN5特异性抗体，发现其在肝癌细胞中异常低表达，并通过调节βV-spectrin的细胞骨架网络抑制肿瘤细胞的迁移和侵袭，提示其作为潜在生物标志物的价值。
2. **标题**：*Developmental expression of SPTBN5 in cerebellar neurons*
**作者**：Smith, J.L. & Patel, R. (2018)
**摘要**：通过免疫组化分析(使用兔源SPTBN5多克隆抗体)，作者发现SPTBN5在小脑浦肯野细胞中高表达，可能通过稳定细胞极性参与神经发育过程中的定向迁移。
3. **标题**：*Generation and validation of a novel polyclonal antibody against human SPTBN5*
**作者**：Lee, H. et al. (2019)
**摘要**：本文报道了一种新型SPTBN5多克隆抗体的开发，通过Western blot和免疫荧光验证其特异性，并证明其适用于检测多种组织样本中的βV-spectrin蛋白表达。
4. **标题**：*SPTBN5 deficiency disrupts cytoskeletal dynamics in mitosis*
**作者**：Johnson, M.T. et al. (2021)
**摘要**：使用CRISPR/Cas9敲除模型和SPTBN5抗体标记，研究发现βV-spectrin缺失导致有丝分裂中纺锤体异常，提示其在细胞分裂中的关键作用。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“SPTBN5 antibody”或“betaV-spectrin”，并筛选近年研究。部分研究可能侧重其与疾病(如癌症、神经退行性疾病)的关联或抗体应用技术。
The SPTBN5 antibody targets the SPTBN5 protein, also known as βV-spectrin, a member of the spectrin family. Spectrins are cytoskeletal proteins critical for maintaining cell shape, membrane integrity, and intracellular transport. SPTBN5. encoded by the SPTBN5 gene, is a non-erythrocytic spectrin isoform predominantly expressed in neuronal tissues, sensory organs (e.g., inner ear hair cells), and certain epithelial cells. It plays roles in stabilizing membrane-associated protein complexes, regulating cell adhesion, and participating in signal transduction pathways. Dysregulation of SPTBN5 has been linked to developmental defects, hearing loss, and neurodegenerative disorders, though its exact mechanisms remain under investigation.
SPTBN5 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze tissue-specific distribution or alterations in disease models. Recent studies highlight its potential involvement in cancer progression, particularly in metastasis and drug resistance, making SPTBN5 antibodies valuable for oncology research. Commercial SPTBN5 antibodies are typically validated for specificity via knockout controls or siRNA knockdown. However, challenges persist in ensuring cross-reactivity across species or detecting splice variants. Continued research aims to clarify SPTBN5's biological significance and therapeutic potential.
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